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TNFAIP3 recombinant protein :: Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) Recombinant Protein

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Catalog # MBS950476
Unit / Price
  0.05 mg (Yeast)  /  $1,220 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $1,225 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,460 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,655 +2 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,665 +2 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,700 +2 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,830 +2 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,885 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $2,110 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,700 +3 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,710 +3 FREE 8GB USB
  1 mg (E-Coli)  /  $2,750 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,970 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $4,170 +5 FREE 8GB USB
TNFAIP3 recombinant protein
Product Name

Tumor necrosis factor alpha-induced protein 3 (TNFAIP3), Recombinant Protein

Full Product Name

Recombinant Human Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-790aa, Full Length of Mature Protein
Sequence
AEQVLPQALY LSNMRKAVKI RERTPEDIFK PTNGIIHHFK TMHRYTLEMF RTCQFCPQFR EIIHKALIDR NIQATLESQK KLNWCREVRK LVALKTNGDG NCLMHATSQY MWGVQDTDLV LRKALFSTLK ETDTRNFKFR WQLESLKSQE FVETGLCYDT RNWNDEWDNL IKMASTDTPM ARSGLQYNSL EEIHIFVLCN ILRRPIIVIS DKMLRSLESG SNFAPLKVGG IYLPLHWPAQ ECYRYPIVLG YDSHHFVPLV TLKDSGPEIR AVPLVNRDRG RFEDLKVHFL TDPENEMKEK LLKEYLMVIE IPVQGWDHGT THLINAAKLD EANLPKEINL VDDYFELVQH EYKKWQENSE QGRREGHAQN PMEPSVPQLS LMDVKCETPN CPFFMSVNTQ PLCHECSERR QKNQNKLPKL NSKPGPEGLP GMALGASRGE AYEPLAWNPE ESTGGPHSAP PTAPSPFLFS ETTAMKCRSP GCPFTLNVQH NGFCERCHNA RQLHASHAPD HTRHLDPGKC QACLQDVTRT FNGICSTCFK RTTAEASSSL STSLPPSCHQ RSKSDPSRLV RSPSPHSCHR AGNDAPAGCL SQAARTPGDR TGTSKCRKAG CVYFGTPENK GFCTLCFIEY RENKHFAAAS GKVSPTASRF QNTIPCLGRE CGTLGSTMFE GYCQKCFIEA QNQRFHEAKR TEEQLRSSQR RDVPRTTQST SRPKCARASC KNILACRSEE LCMECQHPNQ RMGPGAHRGE PAPEDPPKQR CRAPACDHFG NAKCNGYCNE CFQFKQMYG
OMIM
191163
3D Structure
ModBase 3D Structure for P21580
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of TNFAIP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TNFAIP3 recombinant protein
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). This protein is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.
NCBI/Uniprot data below describe general gene information for TNFAIP3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,614 Da
NCBI Official Full Name
tumor necrosis factor alpha-induced protein 3
NCBI Official Synonym Full Names
TNF alpha induced protein 3
NCBI Official Symbol
TNFAIP3  [Similar Products]
NCBI Official Synonym Symbols
A20; AISBL; OTUD7C; TNFA1P2
  [Similar Products]
NCBI Protein Information
tumor necrosis factor alpha-induced protein 3
UniProt Protein Name
Tumor necrosis factor alpha-induced protein 3
UniProt Synonym Protein Names
OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20
UniProt Gene Name
TNFAIP3  [Similar Products]
UniProt Synonym Gene Names
OTUD7C; TNF alpha-induced protein 3  [Similar Products]
NCBI Summary for TNFAIP3
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
UniProt Comments for TNFAIP3
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of proinflammatory cytokines and IFN beta in LPS-tolerized macrophages.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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