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TNFRSF11B recombinant protein :: Osteoprotegerin Recombinant Protein

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Catalog # MBS637329
Unit / Price
  0.01 mg  /  $345 +1 FREE 8GB USB
TNFRSF11B recombinant protein
Product Name

Osteoprotegerin (TNFRSF11B), Recombinant Protein

Popular Item
Also Known As

Osteoprotegerin, Recombinant, Human (OPG, MGC29565, Osteoclastogenesis Inhibitory Factor, OCIF, TR1, Tumor Necrosis Factor Receptor Superfamily Member 11B, TNFRSF11B)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 8; NC_000008.10 (119935796..119964383, complement). Location: 8q24
OMIM
239000
3D Structure
ModBase 3D Structure for O00300
Purity/Purification
Highly Purified
>98% (SDS-PAGE and HPLC).
Form/Format
Supplied as a lyophilized powder. Reconstitute in 5mM Tris, pH 7.5 to a concentration of 0.1-1mg/ml.
Biological Activity
Determined by its ability to neutralize the stimulation of U937 cells treated with 10ng/ml of sRANKL.
Source
E.coli
Endotoxin
<0.1ng/ug.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with Tris. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer
Other Notes
Small volumes of TNFRSF11B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TNFRSF11B recombinant protein
Human OPG (Osteoprotegerin), also known as OCIF (Osteoclastogenesis inhibitory factor), is a member of the TNF receptor superfamily. Recombinant human OPG/OCIF specifically acts on bone tissues and increases bone mineral density and bone volume associated with a decrease of active osteoclast number. Recombinant human OPG is a 20kD protein, comprising of 174 amino acid residues.
NCBI/Uniprot data below describe general gene information for TNFRSF11B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,026 Da[Similar Products]
NCBI Official Full Name
osteoprotegerin
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 11b
NCBI Official Symbol
TNFRSF11B  [Similar Products]
NCBI Official Synonym Symbols
OPG; TR1; OCIF
  [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 11B; osteoprotegerin; osteoclastogenesis inhibitory factor
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 11B
UniProt Synonym Protein Names
Osteoclastogenesis inhibitory factor; Osteoprotegerin
UniProt Gene Name
TNFRSF11B  [Similar Products]
UniProt Synonym Gene Names
OCIF; OPG  [Similar Products]
UniProt Entry Name
TR11B_HUMAN
NCBI Summary for TNFRSF11B
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for TNFRSF11B
TNFRSF11B: Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD); also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal.

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: cytokine activity; receptor activity

Biological Process: response to drug; response to magnesium ion; extracellular matrix organization and biogenesis; apoptosis; negative regulation of odontogenesis of dentine-containing teeth; response to estrogen stimulus; response to arsenic; signal transduction; negative regulation of bone resorption; skeletal development; response to nutrient

Disease: Paget Disease, Juvenile
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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