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TNFRSF13C elisa kit :: Human CD268 ELISA Kit

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Catalog # MBS824623
Unit / Price
  96 Tests  /  $470 +1 FREE 8GB USB
Typical Standard Curve/Testing Data
Product Name

CD268 (TNFRSF13C), ELISA Kit

Popular Item
Full Product Name

Human CD268 ELISA Kit

Product Synonym Names
BAFFR; BR3; Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD268
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
gene 613494
3D Structure
ModBase 3D Structure for Q96RJ3
Species Reactivity
Specificity
The Human CD268 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human CD268 proteins within the range of 78 pg/ml - 5000 pg/ml.
Samples
Serum, plasma
Sensitivity
Typically less than 10 pg/ml.
Preparation and Storage
Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of TNFRSF13C elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forTNFRSF13Cpurchase
MBS824623 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CD268 (TNFRSF13C) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TNFRSF13C. The ELISA analytical biochemical technique of the MBS824623 kit is based on TNFRSF13C antibody-TNFRSF13C antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TNFRSF13C antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TNFRSF13C. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Related Product Information for
TNFRSF13C elisa kit
Principle of the Assay: The Human CD268 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human CD268 in Cell Culture Supernatants, Serum, Plasma. This assay employs an antibody specific for Human CD268 coated on a 96-well plate. Standards and samples are pipetted into the wells and CD268 present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human CD268 antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of CD268 bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm.

Background/Introduction: Tumor necrosis factor receptor superfamily member 13C also known as B-cell-activating factor receptor or BAFF receptor is a protein that in humans is encoded by the TNFRSF13C gene. By homology to a BAC clone, the BAFFR gene was mapped to chromosome 22q13.1-q13.31. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular phenylalanine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Applications Tested/Suitable for TNFRSF13C elisa kit
Sandwich ELISA (SE)

Typical Standard Curve/Testing Data of TNFRSF13C elisa kit
TNFRSF13C elisa kit Typical Standard Curve/Testing Data image
Sample Manual Insert of MBS824623. Click to request current manual
NCBI/Uniprot data below describe general gene information for TNFRSF13C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
18,935 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 13C
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 13C
NCBI Official Symbol
TNFRSF13C  [Similar Products]
NCBI Official Synonym Symbols
BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
  [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BLyS receptor 3; B cell-activating factor receptor; B-cell-activating factor receptor
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 13C
UniProt Synonym Protein Names
B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD_antigen: CD268
UniProt Gene Name
TNFRSF13C  [Similar Products]
UniProt Synonym Gene Names
BAFFR; BR3; BAFF-R  [Similar Products]
UniProt Entry Name
TR13C_HUMAN
NCBI Summary for TNFRSF13C
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
UniProt Comments for TNFRSF13C
BAFF-R: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4); also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Cell cycle regulation; Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 22q13.1-q13.31

Cellular Component: integral to membrane; external side of plasma membrane

Biological Process: B cell costimulation; B cell homeostasis; T cell costimulation; positive regulation of B cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; positive regulation of interferon-gamma biosynthetic process

Disease: Immunodeficiency, Common Variable, 2; Immunodeficiency, Common Variable, 4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with TNFRSF13C elisa kit
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >14 publications with TNFRSF13C and Lymph Node
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