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anti-TNFRSF25 antibody :: Rabbit DR3 (ED) Antibody

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Catalog # MBS194070
Unit / Price
  0.1 mg  /  $400 +1 FREE 8GB USB
anti-TNFRSF25 antibody
Product Name

DR3 (ED) (TNFRSF25), Antibody

Also Known As

Anti-DR3 (ED) Antibody

Product Synonym Names
Anti-DR3 (ED); DR3 (ED)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (6521211..6526255, complement). Location: 1p36.2
OMIM
603366
3D Structure
ModBase 3D Structure for Q93038
Host
Rabbit
Specificity
Anti-DR3 (ED) [Rabbit antibody to extracellular domain of human cell death receptor DR3.]
This antibody recognizes full-length human DR3 (59 kD).
Form/Format
100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Antigen
Peptide corresponding to the extracellular domain of human DR3.
Stabilizer
None
Preservatives
0.02% sodium azide.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of anti-TNFRSF25 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TNFRSF25 antibody
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domaincontaining receptors, TNFR1 and Fas. Another cell death receptor was recently identified and designated DR3, Wsl-1, Apo- 3, TRAMP, and LARD. DR3 is widely expressed in tissues enriched in lymphocytes including peripheral blood, thymus, and spleen. Like TNFR1, DR3 induces apoptosis and NF- kappa B activation.
Product Categories/Family for anti-TNFRSF25 antibody
Applications Tested/Suitable for anti-TNFRSF25 antibody
Immunoblot
Application Notes for anti-TNFRSF25 antibody
Immunoblotting : use at 1:500-1:1,000 dilution.
Positive control: Whole cell lysate from Jurkat cells.
NCBI/Uniprot data below describe general gene information for TNFRSF25. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,385 Da[Similar Products]
NCBI Official Full Name
DR3
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 25
NCBI Official Symbol
TNFRSF25  [Similar Products]
NCBI Official Synonym Symbols
DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12
  [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 25; protein WSL-1; death receptor 3; OTTHUMP00000000922; OTTHUMP00000000923; OTTHUMP00000000924; OTTHUMP00000000925; OTTHUMP00000220969; OTTHUMP00000220970; OTTHUMP00000220971; OTTHUMP00000220974; OTTHUMP00000220975; death receptor beta; apoptosis inducing receptor; apoptosis-inducing receptor AIR; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble form; lymphocyte associated receptor of death; lymphocyte-associated receptor of death; translocating chain-association membrane protein; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 25
UniProt Synonym Protein Names
Apo-3; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; Death receptor 3; Lymphocyte-associated receptor of death; LARD; Protein WSL; Protein WSL-1
UniProt Gene Name
TNFRSF25  [Similar Products]
UniProt Synonym Gene Names
APO3; DDR3; DR3; TNFRSF12; WSL; WSL1  [Similar Products]
UniProt Entry Name
TNR25_HUMAN
NCBI Summary for TNFRSF25
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq]
UniProt Comments for TNFRSF25
TNFRSF25: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Apoptosis

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; cytosol

Molecular Function: tumor necrosis factor receptor activity; receptor activity

Biological Process: regulation of apoptosis; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; apoptosis; signal transduction
Research Articles on TNFRSF25
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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