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TNNI2 elisa kit :: Canine Troponin I Type 2, Fast Skeletal ELISA Kit

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Catalog # MBS080215
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TNNI2 elisa kit
Product Name

Troponin I Type 2, Fast Skeletal (TNNI2), ELISA Kit

Popular Item
Full Product Name

Canine Troponin I Type 2, Fast Skeletal ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
600692
3D Structure
ModBase 3D Structure for P45378
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of TNNI2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for TNNI2purchase
MBS080215 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Troponin I Type 2, Fast Skeletal (TNNI2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TNNI2. The ELISA analytical biochemical technique of the MBS080215 kit is based on TNNI2 antibody-TNNI2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TNNI2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TNNI2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Sample Manual Insert of MBS080215. Click to request current manual
NCBI/Uniprot data below describe general gene information for TNNI2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,825 Da
NCBI Official Full Name
troponin T, fast skeletal muscle isoform 2
NCBI Official Synonym Full Names
troponin T type 3 (skeletal, fast)
NCBI Official Symbol
TNNT3  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
troponin T, fast skeletal muscle; fTnT; beta TnTF; beta-TnTF; troponin-T3, skeletal, fast; fast skeletal muscle troponin T
UniProt Protein Name
Troponin T, fast skeletal muscle
UniProt Synonym Protein Names
Beta-TnTF; Fast skeletal muscle troponin T
Protein Family
UniProt Gene Name
TNNT3  [Similar Products]
UniProt Synonym Gene Names
TnTf; fTnT  [Similar Products]
UniProt Entry Name
TNNT3_HUMAN
NCBI Summary for TNNI2
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
UniProt Comments for TNNI2
TNNT3: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Defects in TNNT3 are a cause of distal arthrogryposis type 2B (DA2B); also known as arthrogryposis multiplex congenita, distal, type 2B (AMCD2B). DA2B is a form of inherited multiple congenital contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin. Belongs to the troponin T family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: troponin complex; cytosol

Molecular Function: troponin C binding; troponin I binding; actin binding; tropomyosin binding; calcium-dependent protein binding; calcium-dependent ATPase activity

Biological Process: skeletal muscle contraction; regulation of ATPase activity; metabolic process; regulation of striated muscle contraction; muscle filament sliding

Disease: Arthrogryposis, Distal, Type 2b
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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