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TNNI3 native protein :: Troponin I-Cardiac, Calibrator Set (NHS base) Native Protein

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Catalog # MBS318330
Unit / Price
  1 Set  /  $1,460 +1 FREE 8GB USB
TNNI3 native protein
Product Name

Troponin I-Cardiac, Calibrator Set (NHS base) (TNNI3), Native Protein

Also Known As

Troponin I-Cardiac Calib. Set

Product Synonym Names
Troponin I Cardiac Calib. Set; Troponin I Cardiac Calibrator Set
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (55663135..55669100, complement). Location: 19q13.4
OMIM
115210
3D Structure
ModBase 3D Structure for P19429
Host
Human Heart
Specificity
Troponin I-Cardiac, Calibrator Set (NHS base)
Purity/Purification
Calibrators contain human blood components
Form/Format
Calibrator, Lyophilized
Reconstitute in 1ml of distilled water into each vial to obtain the concentration of cardiac troponin I, which is indicated on vial.
Concentration
Calibrators correspond to 0, 0.54, 0.90, 2.54, 10.0, 46.5, and 91.0ng/ml cardiac troponin I. Concentrations are indicated on each vial. (lot specific)
Inactivation
Not applicable
Buffer
Normal human serum
Preservative
No
Lyophilized
Yes
Warnings
A blood sample from the tissue donor tested negative for HIV1, HIV2, HCV antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially in
Preparation and Storage
Store lyophilized product at -10 degree C to -20 degree C. After reconstitution, the product is stable for 6 weeks if stored at 2 to 8 degree C. For long term storage, the product is stable for one year if stored at -20 degree C. Aliquot to avoid multiple
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of TNNI3 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for TNNI3 native protein
Applications Tested/Suitable for TNNI3 native protein
EIA/ELISA
Application Notes for TNNI3 native protein
It is advised for each laboratory to establish its own mean and standard deviation for internal research immunoassays of human cardiac troponin I. The indicated concentrations serve as guidelines values only in immunoassays. The variations between laborat
NCBI/Uniprot data below describe general gene information for TNNI3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
24,008 Da[Similar Products]
NCBI Official Full Name
troponin I, cardiac muscle
NCBI Official Synonym Full Names
troponin I type 3 (cardiac)
NCBI Official Symbol
TNNI3  [Similar Products]
NCBI Official Synonym Symbols
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; MGC116817
  [Similar Products]
NCBI Protein Information
troponin I, cardiac muscle
UniProt Protein Name
Troponin I, cardiac muscle
UniProt Synonym Protein Names
Cardiac troponin I
Protein Family
UniProt Gene Name
TNNI3  [Similar Products]
UniProt Synonym Gene Names
TNNC1  [Similar Products]
UniProt Entry Name
TNNI3_HUMAN
NCBI Summary for TNNI3
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq]
UniProt Comments for TNNI3
Function: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Subunit structure: Binds to actin and tropomyosin. Interacts with TRIM63. Ref.7

Involvement in disease: Defects in TNNI3 are the cause of cardiomyopathy familial hypertrophic type 7 (CMH7) [

MIM:613690]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Ref.10 Ref.11 Ref.13 Ref.15 Ref.17Defects in TNNI3 are the cause of cardiomyopathy familial restrictive type 1 (RCM1) [

MIM:115210]. RCM1 is an heart muscle disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.Defects in TNNI3 are the cause of cardiomyopathy dilated type 2A (CMD2A) [

MIM:611880]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Ref.16Defects in TNNI3 are the cause of cardiomyopathy dilated type 1FF (CMD1FF) [

MIM:613286]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

Sequence similarities: Belongs to the troponin I family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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