NP_000355.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
troponin T, cardiac muscle isoform 1
NCBI Official Synonym Full Names
troponin T type 2 (cardiac)
NCBI Official Synonym Symbols
CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6 [Similar Products]
NCBI Protein Information
troponin T, cardiac muscle; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; troponin T2, cardiac
UniProt Protein Name
Troponin T, cardiac muscle
UniProt Synonym Protein Names
Cardiac muscle troponin T; cTnT
UniProt Synonym Gene Names
UniProt Entry Name
TNNT2_HUMAN
NCBI Summary for TNNT2
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for TNNT2
TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament
Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding
Biological Process: positive regulation of ATPase activity; metabolic process; atrial cardiac muscle morphogenesis; regulation of muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding
Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2
Research Articles on TNNT2
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Products associated with TNNT2 native protein
Pathways associated with TNNT2 native protein
Diseases associated with TNNT2 native protein
Disease Name |
Pubmed Publications |
Cardiovascular Diseases Antibodies |
>164 publications with TNNT2 and Cardiovascular Diseases |
Heart Diseases Antibodies |
>160 publications with TNNT2 and Heart Diseases |
Cardiomyopathies Antibodies |
>123 publications with TNNT2 and Cardiomyopathies |
Cardiomyopathy, Hypertrophic Antibodies |
>102 publications with TNNT2 and Cardiomyopathy, Hypertrophic |
Cardiomyopathy, Hypertrophic, Familial Antibodies |
>49 publications with TNNT2 and Cardiomyopathy, Hypertrophic, Familial |
Cardiomyopathy, Dilated Antibodies |
>46 publications with TNNT2 and Cardiomyopathy, Dilated |
Cardiomegaly Antibodies |
>44 publications with TNNT2 and Cardiomegaly |
Hypertrophy Antibodies |
>38 publications with TNNT2 and Hypertrophy |
Heart Failure Antibodies |
>36 publications with TNNT2 and Heart Failure |
Death, Sudden, Cardiac Antibodies |
>34 publications with TNNT2 and Death, Sudden, Cardiac |
Organs/Tissues associated with TNNT2 native protein
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