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TOP3A recombinant protein :: DNA topoisomerase 3-alpha (TOP3A) Recombinant Protein

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Catalog # MBS1288364
Unit / Price
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  0.05 mg (E-Coli)  /  $545 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $710 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $730 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $805 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $860 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $955 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,075 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,080 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,100 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,130 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,570 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,630 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,675 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,100 +2 FREE 8GB USB
TOP3A recombinant protein
Product Name

DNA topoisomerase 3-alpha (TOP3A), Recombinant Protein

Full Product Name

Recombinant Human DNA topoisomerase 3-alpha (TOP3A) , partial

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
32-182. Partial.
Sequence
GVRKVLCVAE KNDAAKGIAD LLSNGRMRRR EGLSKFNKIY EFDYHLYGQN VTMVMTSVSG HLLAHDFQMQ FRKWQSCNPL VLFEAEIEKY CPENFVDIKK TLERETRQCQ ALVIWTDCDR EGENIGFEII HVCKAVKPNL QVLRARFSEI T
OMIM
601243
3D Structure
ModBase 3D Structure for Q13472
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TOP3A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TOP3A recombinant protein
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.
NCBI/Uniprot data below describe general gene information for TOP3A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,208 Da
NCBI Official Full Name
DNA topoisomerase 3-alpha isoform 2
NCBI Official Synonym Full Names
DNA topoisomerase III alpha
NCBI Official Symbol
TOP3A  [Similar Products]
NCBI Official Synonym Symbols
TOP3; ZGRF7
  [Similar Products]
NCBI Protein Information
DNA topoisomerase 3-alpha
UniProt Protein Name
DNA topoisomerase 3-alpha
UniProt Synonym Protein Names
DNA topoisomerase III alpha
Protein Family
UniProt Gene Name
TOP3A  [Similar Products]
UniProt Synonym Gene Names
NCBI Summary for TOP3A
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
UniProt Comments for TOP3A
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with TOP3A recombinant protein
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