NP_073203.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
70,153 Da
NCBI Official Full Name
transferrin receptor protein 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Synonym Symbols
NCBI Protein Information
transferrin receptor protein 1; TR; tfR; tfR1
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
CD_antigen: CD71
UniProt Synonym Gene Names
UniProt Entry Name
TFR1_RAT
NCBI Summary for TR
receptor for transferrin; involved in regulating stellate cell activation [RGD, Feb 2006]
UniProt Comments for TR
TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.
Protein type: Membrane protein, integral; Receptor, misc.; Cell surface
Cellular Component: extracellular space; cell surface; mitochondrion; intracellular membrane-bound organelle; recycling endosome membrane; cell; cytoplasmic membrane-bound vesicle; extracellular region; integral to membrane; coated pit; recycling endosome; perinuclear region of cytoplasm; melanosome; plasma membrane; endosome; vesicle; external side of plasma membrane
Molecular Function: identical protein binding; transferrin receptor activity; chaperone binding; double-stranded RNA binding; Hsp70 protein binding
Biological Process: receptor-mediated endocytosis; response to retinoic acid; response to inorganic substance; cellular iron ion homeostasis; transferrin transport; osteoclast differentiation; regulation of cell proliferation; response to organic substance; response to manganese ion; response to copper ion; acute-phase response; response to hypoxia; positive regulation of bone resorption; regulation of cell growth; response to iron ion; response to nutrient; aging
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Pathways associated with TR elisa kit
Organs/Tissues associated with TR elisa kit
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