• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TRAF6 recombinant protein :: (Rhesus macaque) TNF receptor-associated factor 6 (TRAF6) Recombinant Protein

Scan QR to view Datasheet
Catalog # MBS1027537
Unit / Price
Scan QR to view Datasheet
  1 mg (E-Coli)  /  $2,110 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,570 +3 FREE 8GB USB
TRAF6 recombinant protein
Product Name

(Rhesus macaque) TNF receptor-associated factor 6 (TRAF6), Recombinant Protein

Full Product Name

Recombinant Macaca mulatta (Rhesus macaque) TNF receptor-associated factor 6 (TRAF6)

Product Synonym Gene Name
Recombinant (Rhesus macaque) TNF receptor-associated factor 6 (TRAF6); TNF receptor-associated factor 6 EC= 6.3.2.-; E3 ubiquitin-protein ligase TRAF6[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-522
Sequence
MSLLNCENSC GSSQSESDCC VAMASSCSAA TKDDSVGGTA STGNLSSSFM EDIQGYDVEF DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD NFAKREILSL MVKCPNEGCL HKMELRHLED HQAHCEFALV DCPQCQRPFQ KFHINIHILK DCPRRQVSCD NCAALVAFED KEIHDQNCPL ANVICEYCNT ILIREQMPNH YDLDCPTAPI PCTFSTFGCH EKMQRNHLAR HLQENTQSHM RMLAQAVHSL SLIPDSGYVS EVRNFQETIH QLEGRLVRQD HQIRELTAKM ETQSTYVSEL KRTIRTLEDK VAEIEAQQCN GIYIWKIGNF GMHLKCQEEE KPVVIHSPGF YTGKPGYKLC MRLHLQLPTA QRCANYISLF VHTMQGEYDS HLPWPFQGTI RLTILDQSEA PVRQNHEEIM DAKPDLLAFQ RPTIPRNPKG FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDS GV
Chromosome Location
Chromosome: 14; NC_007871.1 (35315275..35336097). Location: chromosome: 14
3D Structure
ModBase 3D Structure for B6CJY5
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Macaca mulatta (Rhesus macaque)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of TRAF6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TRAF6 recombinant protein
TRAF6
NCBI/Uniprot data below describe general gene information for TRAF6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
59,465 Da[Similar Products]
NCBI Official Full Name
TNF receptor-associated factor 6
NCBI Official Symbol
TRAF6  [Similar Products]
NCBI Protein Information
TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6
UniProt Protein Name
TNF receptor-associated factor 6
UniProt Synonym Protein Names
E3 ubiquitin-protein ligase TRAF6
UniProt Gene Name
TRAF6  [Similar Products]
UniProt Entry Name
TRAF6_MACMU
UniProt Comments for TRAF6
Function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation

By similarity.

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Homotrimer

By similarity. Homooligomer

By similarity. N-terminal region is dimeric while C-terminal region is trimeric; maybe providing a mode of oligomerization. Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, TRAF, TRAF-interacting protein TRIP and TNF receptor associated protein TDP2. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ. Interacts with PELI1, PELI2 and PELI3. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with ZNF675. Interacts with AJUBA. Interacts with TICAM1 and TICAM2. Interacts with ZFAND5. Interacts with ARRB1 and ARRB2. Interacts with MAP3K7 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with UBE2N. Interacts with TGFBR1, HDAC1 and RANGAP1. Interacts with AKT1, AKT2 and AKT3. Interacts (via TRAF domains) with NUMBL (via C-terminal). Interacts (via TRAF domains) with WDR34 (via WD domains). Interacts with RBCK1

By similarity. Interacts with TRAF3IP2

By similarity. Interacts with LIMD1 (via LIM domains)

By similarity. Interacts with RSAD2/viperin

By similarity. Interacts with IFIT3 (via N-terminus)

By similarity.

Subcellular location: Cytoplasm

By similarity. Cytoplasm › cell cortex

By similarity. Nucleus

By similarity. Lipid droplet

By similarity. Note: RSAD2/viperin recruits it to the lipid droplet

By similarity.

Domain: The coiled coil domain mediates homo- and hetero-oligomerization

By similarity.The MATH/TRAF domain binds to receptor cytoplasmic domains

By similarity.

Post-translational modification: Sumoylated on Lys-124, Lys-142 and Lys-453 with SUMO1

By similarity.Polyubiquitinated; after cell stimulation with IL-1-beta or TGF-beta. This ligand-induced cell stimulation leads to dimerization/oligomerization of TRAF6 molecules, followed by auto-ubiquitination which involves UBE2N and UBE2V1 and leads to TRAF6 activation. This 'Lys-63' site-specific poly-ubiquitination appears to be associated with the activation of signaling molecules. Endogenous autoubiquitination occurs only for the cytoplasmic form

By similarity.

Sequence similarities: Belongs to the TNF receptor-associated factor family. A subfamily.Contains 1 MATH domain.Contains 1 RING-type zinc finger.Contains 2 TRAF-type zinc fingers.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000