NP_003831.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,823 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 10D
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
NCBI Official Synonym Symbols
DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4 [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10D; TNF receptor-related receptor for TRAIL; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL receptor with a truncated death domain; decoy receptor 2
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10D
UniProt Synonym Protein Names
Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD_antigen: CD264
UniProt Synonym Gene Names
UniProt Entry Name
TR10D_HUMAN
NCBI Summary for TRAIL-R4
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [provided by RefSeq, Jul 2008]
UniProt Comments for TRAIL-R4
TRAIL-R4: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p21
Cellular Component: integral to membrane
Molecular Function: transmembrane receptor activity; TRAIL binding
Biological Process: apoptosis; signal transduction; negative regulation of apoptosis
Research Articles on TRAIL-R4
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Products associated with TRAIL-R4 elisa kit
Pathways associated with TRAIL-R4 elisa kit
Diseases associated with TRAIL-R4 elisa kit
Organs/Tissues associated with TRAIL-R4 elisa kit
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