NP_001229518.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,387 Da
NCBI Official Full Name
triggering receptor expressed on myeloid cells 1 isoform 2
NCBI Official Synonym Full Names
triggering receptor expressed on myeloid cells 1
NCBI Protein Information
triggering receptor expressed on myeloid cells 1; triggering-receptor TREM1; triggering receptor expressed on monocytes 1
UniProt Protein Name
Triggering receptor expressed on myeloid cells 1
UniProt Synonym Protein Names
Triggering receptor expressed on monocytes 1
UniProt Synonym Gene Names
UniProt Entry Name
TREM1_HUMAN
NCBI Summary for TREM-1
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
UniProt Comments for TREM-1
TREM1: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: integral to membrane; plasma membrane; extracellular region
Molecular Function: receptor activity
Biological Process: neutrophil chemotaxis; innate immune response; cytokine secretion during immune response; blood coagulation; chemokine metabolic process; leukocyte migration; humoral immune response
Research Articles on TREM-1
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Products associated with TREM-1 elisa kit
Pathways associated with TREM-1 elisa kit
Diseases associated with TREM-1 elisa kit
Organs/Tissues associated with TREM-1 elisa kit
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