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TREX1 cdna clone

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Catalog # MBS1276797
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
TREX1 cdna clone
Product Name

TREX1, cDNA Clone

Popular Item
Full Product Name

TREX1 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggccctg gagctcgcag acagggcagg attgtgcagg gaaggcctga gatgtgcttc tgcccacccc ctaccccact ccctcccctt cggatcttaa cactgggcac tcacacaccc accccatgct cctctccagg ctcagcagca ggtacgtacc caaccatggg ctcgcaggcc ctgcccccgg ggcccatgca gaccctcatc tttttcgaca tggaggccac tggcttgccc ttctcccagc ccaaggtcac ggagctgtgc ctgctggctg tccacagatg tgccctggag agccccccca cctctcaggg gccacctccc acagttcctc caccaccgcg tgtggtagac aagctctccc tgtgtgtggc tccggggaag gcctgcagcc ctgcagccag cgagatcaca ggtctgagca cagctgtgct ggcagcgcat gggcgtcaat gttttgatga caacctggcc aacctgctcc tagccttcct gcggcgccag ccacagccct ggtgcctggt ggcacacaat ggtgaccgct acgacttccc cctgctccaa gcagagctgg ctatgctggg cctcaccagt gctctggatg gtgccttctg tgtggatagc atcactgcgc tgaaggccct ggagcgagca agcagcccct cagaacacgg cccaaggaag agctacagcc taggcagcat ctacactcgc ctgtatgggc agtcccctcc agactcgcac acggctgagg gtgatgtcct ggccctgctc agcatctgtc agtggagacc acaggccctg ctgcggtggg tggatgctca cgccaggcct ttcggcacca tcaggcccat gtatggggtc acagcctctg ctaggaccaa gccaagacca tctgctgtca caaccactgc acacctggcc acaaccagga acactagtcc cagccttgga gagagcaggg gtaccaagga tcttcctcca gtgaaggacc ctggagccct atccagggag gggctgctgg ccccactggg tctgctggcc atcctgacct tggcagtagc cacactgtat ggactatccc tggccacacc tggggagtag
OMIM
152700
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of TREX1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TREX1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,212 Da
NCBI Official Full Name
Homo sapiens three prime repair exonuclease 1, mRNA
NCBI Official Synonym Full Names
three prime repair exonuclease 1
NCBI Official Symbol
TREX1  [Similar Products]
NCBI Official Synonym Symbols
CRV; AGS1; DRN3; HERNS
  [Similar Products]
NCBI Protein Information
three-prime repair exonuclease 1
UniProt Protein Name
Three-prime repair exonuclease 1
UniProt Synonym Protein Names
3'-5' exonuclease TREX1; DNase III
UniProt Gene Name
TREX1  [Similar Products]
UniProt Entry Name
TREX1_HUMAN
NCBI Summary for TREX1
This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
UniProt Comments for TREX1
TREX1: the major 3' DNA exonuclease in mammalian cells. Normally associates with the endoplasmic reticulum (ER). Translocates to the nucleus at S phase after DNA damage by gamma-irradiation or hydroxyurea. Trex1-deficient cells show defective G1/S transition, with single-stranded DNA molecules persisting after S phase and accumulating in the ER. Degrades ssDNA. Prevents chronic checkpoint activation and inappropriate immune activation. Mutations cause Aicardi-Goutieres syndrome, an autoimmune disorder. Trex1a(-/-) mice have autoinflammatory responses. The gene for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode TREX1 also encode ATRIP in another reading frame. Three alternatively spliced human isoforms have been reported.

Protein type: EC 3.1.11.2; DNA repair, damage; Cell cycle regulation; Deoxyribonuclease; DNA-binding

Chromosomal Location of Human Ortholog: 3p21.31

Disease: Aicardi-goutieres Syndrome 1; Chilblain Lupus 1; Systemic Lupus Erythematosus; Vasculopathy, Retinal, With Cerebral Leukodystrophy
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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