AAB30957.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
troponin T
NCBI Official Synonym Full Names
troponin T type 2 (cardiac)
NCBI Official Synonym Symbols
CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6; MGC3889 [Similar Products]
NCBI Protein Information
troponin T, cardiac muscle; OTTHUMP00000033864; OTTHUMP00000033865; OTTHUMP00000033866; OTTHUMP00000033867; OTTHUMP00000033870; OTTHUMP00000218095; troponin T2, cardiac; cardiac muscle troponin T; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant)
UniProt Protein Name
Troponin T, cardiac muscle
UniProt Synonym Protein Names
Cardiac muscle troponin T
UniProt Entry Name
TNNT2_HUMAN
NCBI Summary for Troponin T
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq]
UniProt Comments for Troponin T
Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Tissue specificity: Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.
Involvement in disease: Defects in TNNT2 are the cause of cardiomyopathy familial hypertrophic type 2 (CMH2) [
MIM:115195]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Ref.6 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.24 Ref.26 Ref.28 Ref.30Defects in TNNT2 are the cause of cardiomyopathy dilated type 1D (CMD1D) [
MIM:601494]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Ref.22 Ref.23 Ref.27 Ref.29Defects in TNNT2 are the cause of cardiomyopathy familial restrictive type 3 (RCM3) [
MIM:612422]. Restrictive cardiomyopathy is a heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
Sequence similarities: Belongs to the troponin T family.
Research Articles on Troponin T
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Products associated with anti-Troponin T antibody
Pathways associated with anti-Troponin T antibody
Diseases associated with anti-Troponin T antibody
Disease Name |
Pubmed Publications |
Heart Diseases Antibodies |
>83 publications with Troponin T and Heart Diseases |
Cardiovascular Diseases Antibodies |
>81 publications with Troponin T and Cardiovascular Diseases |
Cardiomyopathies Antibodies |
>73 publications with Troponin T and Cardiomyopathies |
Cardiomyopathy, Dilated Antibodies |
>30 publications with Troponin T and Cardiomyopathy, Dilated |
Cardiomegaly Antibodies |
>29 publications with Troponin T and Cardiomegaly |
Genetic Diseases, Inborn Antibodies |
>28 publications with Troponin T and Genetic Diseases, Inborn |
CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 2 Antibodies |
>22 publications with Troponin T and CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 2 |
Heart Failure Antibodies |
>15 publications with Troponin T and Heart Failure |
Ventricular Dysfunction, Left Antibodies |
>6 publications with Troponin T and Ventricular Dysfunction, Left |
Hypertension Antibodies |
>4 publications with Troponin T and Hypertension |
Organs/Tissues associated with anti-Troponin T antibody
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