NP_004612.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
100,106 Da
NCBI Official Full Name
short transient receptor potential channel 6
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily C, member 6
NCBI Official Synonym Symbols
NCBI Protein Information
short transient receptor potential channel 6
UniProt Protein Name
Short transient receptor potential channel 6
UniProt Synonym Protein Names
Transient receptor protein 6; TRP-6
UniProt Synonym Gene Names
UniProt Entry Name
TRPC6_HUMAN
NCBI Summary for TRPC6
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
UniProt Comments for TRPC6
TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q22.1
Cellular Component: plasma membrane; integral to membrane
Molecular Function: protein binding; store-operated calcium channel activity
Biological Process: axon guidance; positive regulation of ion transmembrane transporter activity; platelet activation; elevation of cytosolic calcium ion concentration; blood coagulation; positive regulation of calcium ion transport; transmembrane transport; cation transport; aging
Disease: Focal Segmental Glomerulosclerosis 2
Research Articles on TRPC6
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Products associated with TRPC6 sirna
Pathways associated with TRPC6 sirna
Diseases associated with TRPC6 sirna
Organs/Tissues associated with TRPC6 sirna
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