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TSHR recombinant protein :: Thyrotropin receptor (TSHR) Recombinant Protein

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Catalog # MBS949648
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TSHR recombinant protein
Product Name

Thyrotropin receptor (TSHR), Recombinant Protein

Full Product Name

Recombinant Sheep Thyrotropin receptor (TSHR)

Product Synonym Names
Recombinant Thyrotropin receptor (TSHR); Thyrotropin receptor; Thyroid-stimulating hormone receptor; TSH-R
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
22-413aa; Fragment at the N-terminal, provide the extracellular domain.
Sequence
ERCPSPPCEC RQEDDFRVTC KDIQRIPSLP PSTQTLKFIE THLKTIPSRA FSNLPNISRI YLSIDATLQQ LESHSFYNLS KVTHIEIRNT RSLTYIDSGA LKELPLLKFL GIFNTGLRVF PDLTKIYSTD VFFILEITDN PYMTSVPANA FQGLSNETLT LKLYNNGFTS IQGHAFNGTK LDAVYLNKNK YLTVIDQDAF AGVYSGPTLL DISYTSVTAL PSKGLEHLKE LIARNTWTLK KLPLSLSFLH LTRADLSYPS HCCAFKNQKN IRGILQSLMC NESSIWGLRQ RKSASALNGP FYQEYEEDLG DGSAGYKENS KFQDTHSNSH YYVFFEDQED EIIGFGQELK NPQEETLQAF DNHYDYTVCG GSEEMVCTPK SDEFNPCEDI MG
Chromosome Location
Chromosome: 7; NC_019464.1 (89258689..89433026). Location: chromosome: 7
3D Structure
ModBase 3D Structure for P56495
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Ovis aries (Sheep)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TSHR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TSHR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
86,674 Da[Similar Products]
NCBI Official Full Name
thyrotropin receptor
NCBI Official Symbol
NCBI Protein Information
thyrotropin receptor; TSH-R; thyroid-stimulating hormone receptor
UniProt Protein Name
Thyrotropin receptor
UniProt Synonym Protein Names
Thyroid-stimulating hormone receptor
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
TSH-R  [Similar Products]
UniProt Entry Name
TSHR_SHEEP
UniProt Comments for TSHR
Function: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).

Subunit structure: Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.Contains 6 LRR (leucine-rich) repeats.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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