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TX-A2 elisa kit :: Human Thromboxane A2 ELISA Kit

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Catalog # MBS020509
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TX-A2 elisa kit
Product Name

Thromboxane A2 (TX-A2), ELISA Kit

Popular Item
Also Known As

Human Thromboxane A2 ELISA Kit

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Sequence Length
343
OMIM
188070
3D Structure
ModBase 3D Structure for P21731
Species Reactivity
Specificity
No significant cross-reactivity or interference between this analyte and analogues is observed.
Samples
Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Assay Type
Sandwich
Detection Range
31.2 pg/ml - 1000 pg/ml.
Sensitivity
5.0 pg/ml.
Intra-assay Precision
Intra-assay CV (%) is less than 15%.
Inter-assay Precision
Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of TX-A2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forTX-A2purchase
MBS020509 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Thromboxane A2 (TX-A2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TX-A2. The ELISA analytical biochemical technique of the MBS020509 kit is based on TX-A2 antibody-TX-A2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TX-A2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TX-A2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Related Product Information for
TX-A2 elisa kit
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TXA2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS020509. Click to request current manual
NCBI/Uniprot data below describe general gene information for TX-A2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,431 Da
NCBI Official Full Name
thromboxane A2 receptor isoform alpha
NCBI Official Synonym Full Names
thromboxane A2 receptor
NCBI Official Symbol
TBXA2R  [Similar Products]
NCBI Official Synonym Symbols
TXA2-R; BDPLT13
  [Similar Products]
NCBI Protein Information
thromboxane A2 receptor; prostanoid TP receptor
UniProt Protein Name
Thromboxane A2 receptor
UniProt Synonym Protein Names
Prostanoid TP receptor
Protein Family
UniProt Gene Name
TBXA2R  [Similar Products]
UniProt Synonym Gene Names
TXA2-R  [Similar Products]
UniProt Entry Name
TA2R_HUMAN
NCBI Summary for TX-A2
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for TX-A2
TXA2-R: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13). BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: integral to plasma membrane; plasma membrane; acrosome

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; thromboxane A2 receptor activity

Biological Process: response to drug; second-messenger-mediated signaling; platelet activation; response to lipopolysaccharide; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; positive regulation of vasoconstriction; positive regulation of smooth muscle contraction; blood coagulation; inflammatory response; positive regulation of blood pressure; response to nutrient; positive regulation of GTPase activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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