NP_963998.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,205 Da
NCBI Official Full Name
thromboxane A2 receptor isoform beta
NCBI Official Synonym Full Names
thromboxane A2 receptor
NCBI Protein Information
thromboxane A2 receptor; prostanoid TP receptor
UniProt Protein Name
Thromboxane A2 receptor
UniProt Synonym Protein Names
Prostanoid TP receptor
UniProt Synonym Gene Names
UniProt Entry Name
TA2R_HUMAN
NCBI Summary for TX-A2
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for TX-A2
TXA2-R: Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. Defects in TBXA2R are the cause of susceptibility to bleeding disorder platelet-type 13 (BDPLT13). BDPLT13 is a disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: integral to plasma membrane; acrosome; plasma membrane
Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; thromboxane A2 receptor activity
Biological Process: second-messenger-mediated signaling; response to drug; platelet activation; response to lipopolysaccharide; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of angiogenesis; positive regulation of vasoconstriction; positive regulation of smooth muscle contraction; inflammatory response; blood coagulation; positive regulation of blood pressure; response to nutrient; positive regulation of GTPase activity
Research Articles on TX-A2
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Products associated with TX-A2 elisa kit
Pathways associated with TX-A2 elisa kit
Diseases associated with TX-A2 elisa kit
Organs/Tissues associated with TX-A2 elisa kit
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