NP_001139021.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,629 Da
NCBI Official Full Name
thioredoxin domain-containing protein 5 isoform 3
NCBI Official Synonym Full Names
thioredoxin domain containing 5 (endoplasmic reticulum)
NCBI Official Synonym Symbols
ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI [Similar Products]
NCBI Protein Information
thioredoxin domain-containing protein 5; ER protein 46; thioredoxin related protein; thioredoxin-like protein p46; endoplasmic reticulum protein ERp46; endothelial protein disulphide isomerase; endoplasmic reticulum resident protein 46; protein disulfide isomerase family A, member 15
UniProt Protein Name
Thioredoxin domain-containing protein 5
UniProt Synonym Protein Names
Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46
UniProt Synonym Gene Names
UniProt Entry Name
TXND5_HUMAN
NCBI Summary for TXNDC5
This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene. [provided by RefSeq, Dec 2010]
UniProt Comments for TXNDC5
TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p24.3
Cellular Component: lysosomal lumen; endoplasmic reticulum; endoplasmic reticulum lumen
Molecular Function: protein binding; protein disulfide isomerase activity
Biological Process: protein folding; cell redox homeostasis; post-Golgi vesicle-mediated transport; apoptotic cell clearance; negative regulation of apoptosis
Research Articles on TXNDC5
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Pathways associated with TXNDC5 elisa kit
Diseases associated with TXNDC5 elisa kit
Organs/Tissues associated with TXNDC5 elisa kit
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