NP_060734.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
NCBI Official Synonym Full Names
tRNA-yW synthesizing protein 1 homolog
NCBI Protein Information
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
UniProt Protein Name
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
UniProt Synonym Protein Names
Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW-synthesizing protein
UniProt Synonym Gene Names
UniProt Entry Name
TYW1_HUMAN
NCBI Summary for TYW1
Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for TYW1
TYW1: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Belongs to the TYW1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; RNA processing; EC 4.1.3.44
Chromosomal Location of Human Ortholog: 7q11.21
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: FMN binding; 4 iron, 4 sulfur cluster binding; iron ion binding; lyase activity; oxidoreductase activity
Biological Process: tRNA processing
Research Articles on TYW1
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Products associated with TYW1 blocking peptide
Pathways associated with TYW1 blocking peptide
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