NP_060734.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,700 Da
NCBI Official Full Name
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
NCBI Official Synonym Full Names
tRNA-yW synthesizing protein 1 homolog
NCBI Protein Information
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
UniProt Protein Name
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
UniProt Synonym Protein Names
Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW-synthesizing protein
UniProt Synonym Gene Names
NCBI Summary for TYW1
Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for TYW1
Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis ().
Research Articles on TYW1
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Products associated with TYW1 recombinant protein
Pathways associated with TYW1 recombinant protein
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