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UBE2A recombinant protein :: Ubiquitin Conjugating Enzyme E2A Recombinant Protein

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Catalog # MBS144074
Unit / Price
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  0.005 mg  /  $140 +1 FREE 8GB USB
  0.025 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,235 +2 FREE 8GB USB
UBE2A recombinant protein
Product Name

Ubiquitin Conjugating Enzyme E2A (UBE2A), Recombinant Protein

Full Product Name

Recombinant Human Ubiquitin Conjugating Enzyme E2A

Product Synonym Names
UBE2A Human; Ubiquitin Conjugating Enzyme E2A Human Recombinant; HHR6A; HR6A; RAD6A; UBC2; UBE2A; EC=6.3.2.19; Ubiquitin-conjugating enzyme E2 A; Ubiquitin-protein ligase A; Ubiquitin carrier protein A; RAD6 homolog A
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MSTPARRRLM RDFKRLQEDP PAGVSGAPSE NNIMVWNAVI FGPEGTPFED GTFKLTIEFT EEYPNKPPTV RFVSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS PANSQAAQLY QENKREYEKR VSAIVEQSWR DC
OMIM
300860
3D Structure
ModBase 3D Structure for P49459
Host
E Coli
Purity/Purification
Greater than 95% as determined by SDS-PAGE.
Form/Format
UBE2A Human solution containing 20mM Trsi HCL pH-8, 1mM DTT, 1mM EDTA & 10% glycerol.
Sterile filtered colorless solution.
Preparation and Storage
UBE2A Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.
Other Notes
Small volumes of UBE2A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
UBE2A recombinant protein
Description: UBE2A Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 172 amino acids (1-152 a.a.) and having a molecular mass of 19.4 kDa. UBE2A protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.

Introduction: The alteration of proteins with ubiquitin is a vital cellular mechanism for targeting atypical or short-lived proteins for degradation. Ubiquitination involves noT less than three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2A is part of the E2 ubiquitin-conjugating enzyme family. UBE2A is necessary for post-replicative DNA damage repair. UBE2A catalyzes the covalent attachment of ubiquitin to other proteins. UBE2A is necessary for postreplication repair of UV-damaged DNA.
NCBI/Uniprot data below describe general gene information for UBE2A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
8,833 Da
NCBI Official Full Name
ubiquitin-conjugating enzyme E2 A isoform 4
NCBI Official Synonym Full Names
ubiquitin-conjugating enzyme E2A
NCBI Official Symbol
UBE2A  [Similar Products]
NCBI Official Synonym Symbols
UBC2; HHR6A; MRXSN; RAD6A; MRXS30
  [Similar Products]
NCBI Protein Information
ubiquitin-conjugating enzyme E2 A; RAD6 homolog A; ubiquitin carrier protein A; ubiquitin-protein ligase A
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 A
UniProt Synonym Protein Names
RAD6 homolog A; HR6A; hHR6A; Ubiquitin carrier protein A; Ubiquitin-protein ligase A
UniProt Gene Name
UBE2A  [Similar Products]
UniProt Synonym Gene Names
RAD6A; HR6A; hHR6A  [Similar Products]
UniProt Entry Name
UBE2A_HUMAN
NCBI Summary for UBE2A
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for UBE2A
UBE2A: a ubiquitin-protein ligase, a member of the ubiquitin-conjugating enzyme family. Homologous to the yeast DNA repair gene RAD6. Interacts with RAD18. Required for postreplication repair of UV-damaged DNA.

Protein type: Ubiquitin ligase; EC 6.3.2.19; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: Xq24

Cellular Component: XY body; cytoplasm; nuclear chromatin; chromatin; cytosol

Molecular Function: protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of peptide antigen via MHC class I; protein autoubiquitination; maternal process involved in pregnancy; protein polyubiquitination; postreplication repair; in utero embryonic development; positive regulation of cell proliferation; DNA repair; histone H2A ubiquitination; response to UV

Disease: Mental Retardation, X-linked, Syndromic, Nascimento Type
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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