NP_003332
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
ubiquitin-conjugating enzyme E2 E1 isoform 1
NCBI Official Synonym Full Names
ubiquitin conjugating enzyme E2 E1
NCBI Official Synonym Symbols
NCBI Protein Information
ubiquitin-conjugating enzyme E2 E1
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 E1
UniProt Synonym Protein Names
UbcH6; Ubiquitin carrier protein E1; Ubiquitin-protein ligase E1
UniProt Synonym Gene Names
UniProt Entry Name
UB2E1_HUMAN
NCBI Summary for UBE2E1
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for UBE2E1
UBE2E1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family.
Protein type: Ubiquitin ligase; Ligase; EC 6.3.2.19; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 3p24.2
Cellular Component: nucleoplasm; cytosol; nucleus; ubiquitin ligase complex
Molecular Function: protein binding; ISG15 conjugating enzyme activity; ubiquitin-protein ligase activity; ATP binding; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; ISG15-protein conjugation; histone monoubiquitination; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytokine and chemokine mediated signaling pathway; mitotic cell cycle spindle assembly checkpoint; histone H2B ubiquitination; protein ubiquitination; mitotic cell cycle
Research Articles on UBE2E1
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Products associated with UBE2E1 blocking peptide
Pathways associated with UBE2E1 blocking peptide
Diseases associated with UBE2E1 blocking peptide
Organs/Tissues associated with UBE2E1 blocking peptide
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