BC010549
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,158 Da
NCBI Official Full Name
Homo sapiens ubiquitin-conjugating enzyme E2F (putative), mRNA
NCBI Official Synonym Full Names
ubiquitin conjugating enzyme E2 F (putative)
NCBI Official Synonym Symbols
NCBI Protein Information
NEDD8-conjugating enzyme UBE2F
UniProt Protein Name
NEDD8-conjugating enzyme UBE2F
UniProt Synonym Protein Names
NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; Ubiquitin-conjugating enzyme E2 F
UniProt Synonym Gene Names
UniProt Entry Name
UBE2F_HUMAN
UniProt Comments for UBE2F
UBE2F: Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cytoplasm; nucleus
Molecular Function: NEDD8 ligase activity; protein binding; ubiquitin protein ligase binding
Biological Process: postreplication repair; protein neddylation
Research Articles on UBE2F
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Pathways associated with UBE2F cdna clone
Organs/Tissues associated with UBE2F cdna clone
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