NP_001101463.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
37,026 Da
NCBI Official Full Name
ubiA prenyltransferase domain-containing protein 1
NCBI Official Synonym Full Names
UbiA prenyltransferase domain containing 1
NCBI Official Synonym Symbols
NCBI Protein Information
ubiA prenyltransferase domain-containing protein 1
UniProt Protein Name
UbiA prenyltransferase domain-containing protein 1
UniProt Comments for Ubiad1
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress ().
Research Articles on Ubiad1
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Diseases associated with Ubiad1 recombinant protein
Organs/Tissues associated with Ubiad1 recombinant protein
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