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uGDH recombinant protein

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Catalog # MBS203653
Unit / Price
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  0.05 mg  /  $310 +1 FREE 8GB USB
  0.25 mg  /  $720 +1 FREE 8GB USB
SDS-Page
Product Name

uGDH, Recombinant Protein

Popular Item
Full Product Name

uGDH, 1-494aa, Human, His tag, E Coli (Bioactivity Validated)

Product Synonym Names
uDP-glucose dehydrogenase; GDH; uDP-GlcDH; uDPGDH; uGD; uDP-glucose dehydrogenase; uDP-glucose 6-dehydrogenase
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELEM FEIKKICCIG AGYVGGPTCS VIAHMCPEIR VTVVDVNESR INAWNSPTLP IYEPGLKEVV ESCRGKNLFF STNIDDAIKE ADLVFISVNT PTKTYGMGKG RAADLKYIEA CARRIVQNSN GYKIVTEKST VPVRAAESIR RIFDANTKPN LNLQVLSNPE FLAEGTAIKD LKNPDRVLIG GDETPEGQRA VQALCAVYEH WVPREKILTT NTWSSELSKL AANAFLAQRI SSINSISALC EATGADVEEV ATAIGMDQRI GNKFLKASVG FGGSCFQKDV LNLVYLCEAL NLPEVARYWQ QVIDMNDYQR RRFASRIIDS LFNTVTDKKI AILGFAFKKD TGDTRESSSI YISKYLMDEG AHLHIYDPKV PREQIVVDLS HPGVSEDDQV SRLVTISKDP YEACDGAHAV VICTEWDMFK ELDYERIHKK MLKPAFIFDG RRVLDGLHNE LQTIGFQIET IGKKVSSKRI PYAPSGEIPK FSLQDPPNKK PKV
OMIM
AF061016 mRNA
3D Structure
ModBase 3D Structure for O60701
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 1mM DTT, 0.1M NaCl, and 1mM EDTA.
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Tag Information
His-tag
Biological Activity
Specific activity is > 2500 pmol/min/ug, and is defined as the amount of enzyme that convert 1.0pmole of UDP-glucose to UDP-glucuronate per minute at pH 8.7 at 37C.
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of uGDH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
uGDH recombinant protein
uGDH is a member of the uDP-glucose/GDP-mannose dehydrogenase family and is a ubiquitously expressed protein most abundant in the liver. This protein converts uDP-glucose to uDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. Recombinant human uGDH protein, fused to his-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques
Product Categories/Family for uGDH recombinant protein
Applications Tested/Suitable for uGDH recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for uGDH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59.5 kDa (533aa) confirmed by MALDI-TOF
NCBI Official Full Name
UDP-glucose 6-dehydrogenase isoform 1
NCBI Official Synonym Full Names
UDP-glucose 6-dehydrogenase
NCBI Official Symbol
NCBI Official Synonym Symbols
GDH; UGD; UDPGDH; UDP-GlcDH
  [Similar Products]
NCBI Protein Information
UDP-glucose 6-dehydrogenase
UniProt Protein Name
UDP-glucose 6-dehydrogenase
UniProt Gene Name
UniProt Synonym Gene Names
UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH  [Similar Products]
NCBI Summary for uGDH
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for uGDH
Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
Product References and Citations for uGDH recombinant protein
Bontemps Y., et al. (2003) J Biol Chem. 278 (24):21566-75. ; Vatsyayan J., et al. (2006) Biosci Biotechnol Biochem. 70 (2):401-10. ;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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