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US12 recombinant protein :: ICP47 protein (US12) Recombinant Protein

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Catalog # MBS1081523
Unit / Price
  0.05 mg (E-Coli)  /  $475 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $635 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $700 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $810 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $880 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $990 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $990 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,015 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,045 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,480 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,500 +1 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,600 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $1,985 +2 FREE 8GB USB
US12 recombinant protein
Product Name

ICP47 protein (US12), Recombinant Protein

Also Known As

Recombinant Human herpesvirus 2 ICP47 protein (US12)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-86@aa, full length protein
Sequence Length
86
Sequence
MSWALKTTDM FLDSSRCTHR TYGDVCAEIH KREREDREAA RTAVTDPELP LLCPPDVRSD PASRNPTQQT RGCARSNERQ DRVLAP
3D Structure
ModBase 3D Structure for P14345
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of US12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for US12. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
Molecular Weight
9,785 Da
NCBI Official Full Name
TAP transporter inhibitor ICP47
NCBI Official Symbol
NCBI Protein Information
inhibits antigen presentation; involved in immune regulation
UniProt Protein Name
ICP47 protein
UniProt Synonym Protein Names
Immediate-early protein IE12; Immediate-early-5; Infected cell protein 47; US12 protein; Vmw12
Protein Family
UniProt Gene Name
UniProt Comments for US12
Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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