NP_009055.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
155,026 Da
NCBI Official Full Name
utrophin
NCBI Official Synonym Full Names
utrophin
NCBI Protein Information
utrophin; DRP-1; dystrophin-related protein 1
UniProt Protein Name
Utrophin
UniProt Synonym Protein Names
Dystrophin-related protein 1; DRP-1
UniProt Synonym Gene Names
UniProt Entry Name
UTRO_HUMAN
NCBI Summary for UTRN
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for UTRN
utrophin: May play a role in anchoring the cytoskeleton to the plasma membrane.
Protein type: Motility/polarity/chemotaxis; Dystrophin complex
Chromosomal Location of Human Ortholog: 6q24
Cellular Component: dystrophin-associated glycoprotein complex; nucleoplasm; filopodium membrane; postsynaptic membrane; cytoskeleton; protein complex; membrane; cytoplasm; plasma membrane; cell junction; neuromuscular junction; filopodium
Molecular Function: integrin binding; protein binding; zinc ion binding; actin binding; protein kinase binding; vinculin binding
Biological Process: muscle development; muscle contraction; positive regulation of cell-matrix adhesion
Research Articles on UTRN
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Products associated with UTRN elisa kit
Diseases associated with UTRN elisa kit
Organs/Tissues associated with UTRN elisa kit
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