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VANGL2 peptide

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Catalog # MBS426143
Unit / Price
  0.1 mg  /  $190 +1 FREE 8GB USB
VANGL2 peptide
Product Name

VANGL2, Peptide

Full Product Name

VANGL2 Immunizing Peptide

Product Synonym Names
VANGL2; vang-like 2 (van gogh, Drosophila); KIAA1215; LPP1; LTAP; MGC119403; MGC119404; STBM; homolog of Drosophila strabismus; loop-tail-associated protein; vang (van gogh, Drosophila)-like 2; vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (D; VANGL2
Product Gene Name
Antibody/Peptide Pairs
VANGL2 peptide (MBS426143) is used for blocking the activity of VANGL2 antibody (MBS420727)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
C-QKYLRTTK QQPYH
OMIM
182940
Species Reactivity
Human, Mouse, Cow, Zebrafish
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of VANGL2 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for VANGL2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,714 Da
NCBI Official Full Name
vang-like protein 2
NCBI Official Synonym Full Names
VANGL planar cell polarity protein 2
NCBI Official Symbol
VANGL2  [Similar Products]
NCBI Official Synonym Symbols
LPP1; LTAP; STB1; STBM; STBM1
  [Similar Products]
NCBI Protein Information
vang-like protein 2
UniProt Protein Name
Vang-like protein 2
UniProt Synonym Protein Names
Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2
Protein Family
UniProt Gene Name
VANGL2  [Similar Products]
UniProt Synonym Gene Names
KIAA1215; STB1  [Similar Products]
UniProt Entry Name
VANG2_HUMAN
NCBI Summary for VANGL2
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
UniProt Comments for VANGL2
VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Membrane protein, multi-pass; Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: apical plasma membrane; basolateral plasma membrane; ER to Golgi transport vesicle; integral to membrane; intercellular junction; lateral plasma membrane; plasma membrane; stress fiber

Molecular Function: protein binding

Biological Process: anterior/posterior pattern formation; apical protein localization; convergent extension involved in axis elongation; convergent extension involved in neural plate elongation; digestive tract morphogenesis; establishment and/or maintenance of epithelial cell polarity; establishment of body hair orientation; establishment of planar polarity; glomerulus development; hair follicle development; heart looping; heparan sulfate proteoglycan biosynthetic process; inner ear receptor stereocilium organization and biogenesis; neural tube closure; positive regulation of JNK activity; regulation of actin cytoskeleton organization and biogenesis; regulation of Wnt receptor signaling pathway; Rho protein signal transduction; sensory cilium biogenesis; somatic stem cell division; somatic stem cell maintenance; wound healing

Disease: Neural Tube Defects
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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