NP_976080.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
17,783 Da
NCBI Official Full Name
vitamin K epoxide reductase complex subunit 1
NCBI Official Synonym Full Names
vitamin K epoxide reductase complex, subunit 1
NCBI Protein Information
vitamin K epoxide reductase complex subunit 1; Warfarin resistance; phylloquinone epoxide reductase; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive)
UniProt Protein Name
Vitamin K epoxide reductase complex subunit 1
UniProt Synonym Protein Names
Vitamin K1 2,3-epoxide reductase subunit 1
UniProt Entry Name
VKOR1_RAT
NCBI Summary for VK1
Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. [provided by RefSeq, Jul 2008]
UniProt Comments for VK1
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
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Pathways associated with VK1 elisa kit
Diseases associated with VK1 elisa kit
Organs/Tissues associated with VK1 elisa kit
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