AJE63371.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
17,783 Da
NCBI Official Full Name
VKORC1, partial
NCBI Official Synonym Full Names
vitamin K epoxide reductase complex subunit 1
NCBI Official Synonym Symbols
VKOR; MST134; MST576; VKCFD2; EDTP308 [Similar Products]
NCBI Protein Information
vitamin K epoxide reductase complex subunit 1
UniProt Protein Name
Vitamin K epoxide reductase complex subunit 1
UniProt Synonym Protein Names
Vitamin K1 2,3-epoxide reductase subunit 1
UniProt Entry Name
VKOR1_RAT
NCBI Summary for VKORC1
This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
UniProt Comments for VKORC1
Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
Research Articles on VKORC1
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Products associated with VKORC1 blocking peptide
Pathways associated with VKORC1 blocking peptide
Diseases associated with VKORC1 blocking peptide
Organs/Tissues associated with VKORC1 blocking peptide
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