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VPS35 peptide :: VPS35 / MEM3 Peptide

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Catalog # MBS426803
Unit / Price
  0.1 mg  /  $190 +1 FREE 8GB USB
VPS35 peptide
Product Name

VPS35 / MEM3, Peptide

Full Product Name

VPS35 / MEM3 Immunizing Peptide

Product Synonym Names
VPS35; MEM3; FLJ10752; FLJ13588; FLJ20388; DKFZp434E1211; DKFZp434P1672; vacuolar protein sorting 35 (yeast); maternal-embryonic 3; vacuolar protein sorting 35 homolog (S. cerevisiae); vacuolar protein sorting 35; VPS35 / MEM3
Product Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
C-SPESEGPI YEGLIL
OMIM
601501
Species Reactivity
Human, Mouse, Rat, Cow
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of VPS35 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for VPS35. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
91,707 Da
NCBI Official Full Name
vacuolar protein sorting-associated protein 35
NCBI Official Synonym Full Names
VPS35 retromer complex component
NCBI Official Symbol
VPS35  [Similar Products]
NCBI Official Synonym Symbols
MEM3; PARK17
  [Similar Products]
NCBI Protein Information
vacuolar protein sorting-associated protein 35
UniProt Protein Name
Vacuolar protein sorting-associated protein 35
UniProt Synonym Protein Names
Maternal-embryonic 3; Vesicle protein sorting 35
UniProt Gene Name
VPS35  [Similar Products]
UniProt Synonym Gene Names
MEM3; hVPS35  [Similar Products]
UniProt Entry Name
VPS35_HUMAN
NCBI Summary for VPS35
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]
UniProt Comments for VPS35
VPS35: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Defects in VPS35 are the cause of Parkinson disease type 17 (PARK17). PARK17 is an autosomal dominant, adult- onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. Belongs to the VPS35 family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 16q12

Cellular Component: cytosol; early endosome; endosome; late endosome; lysosomal membrane; retromer complex

Molecular Function: protein binding; protein transporter activity

Biological Process: intracellular protein transport; regulation of macroautophagy; regulation of protein stability; retrograde transport, endosome to Golgi; transcytosis; Wnt receptor signaling pathway

Disease: Parkinson Disease 17
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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