• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

VWF native protein

Scan QR to view Datasheet
Catalog # MBS537347
Unit / Price
  0.1 mg  /  $795 +1 FREE 8GB USB
VWF native protein
Product Name

VWF, Native Protein

Also Known As

VWF protein (Factor VIII Free)

Product Synonym Names
Von Willebrand Factor VIII Free Protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
2813
3D Structure
ModBase 3D Structure for Q8CIZ8
Host
Human
Purity/Purification
> 95% pure
Form/Format
25mM sodium citrate, 100mM NaCl, 100mM Glycine, pH 6.8.
Source Note
Human serum/plasma
Protein Type
Native
Biological Significance
Von Willebrand factor (vWF) is a multimeric plasma glycoprotein that is required for normal hemostatic platelet plug formation. The mature plasma protein is composed of apparently identical subunits (Mr=260,000) which are held together by disulfide bonds. The circulating vWF molecule ranges in size from dimers (Mr=520,000) to extremely large multimers (Mr>10,000,000). During normal hemostasis, the larger multimers of vWF are responsible for facilitating platelet plug formation by forming a bridge between platelet glycoprotein IB and exposed collagen in the subendothelium.
Biohazard Information
Donor samples were tested and found to be negative for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Aliquot and store at -80 degree C or lower. Avoid repeated freeze/thaw cycles
Other Notes
Small volumes of VWF native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
VWF native protein
Purified native Human VWF protein (Factor VIII Free)
Product Categories/Family for VWF native protein
Applications Tested/Suitable for VWF native protein
User optimized
NCBI/Uniprot data below describe general gene information for VWF. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
260 kDa
NCBI Official Full Name
VWF
NCBI Official Synonym Full Names
Von Willebrand factor homolog
NCBI Official Symbol
NCBI Official Synonym Symbols
VWD; F8VWF; AI551257; C630030D09; 6820430P06Rik; B130011O06Rik
  [Similar Products]
NCBI Protein Information
von Willebrand factor
UniProt Protein Name
von Willebrand factor
UniProt Synonym Protein Names
von Willebrand antigen 2Alternative name(s):von Willebrand antigen II
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
VWF_MOUSE
UniProt Comments for VWF
VWF: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease type 1 (VWD1). A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 2 (VWD2). A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet- dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 3 (VWD3). A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.

Protein type: Extracellular matrix; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Cell adhesion

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; endoplasmic reticulum; extracellular region; external side of plasma membrane

Molecular Function: collagen binding; integrin binding; identical protein binding; protein binding; protein homodimerization activity; protease binding; chaperone binding; protein N-terminus binding; immunoglobulin binding; glycoprotein binding

Biological Process: platelet activation; hemostasis; cell adhesion; blood coagulation; liver development; protein homooligomerization; cell-substrate adhesion; placenta development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000