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VWFCP/ADAMTS13 clia kit :: Human VWFCP/ADAMTS13 (Von Willebrand Factor Cleaving Protease) CLIA Kit

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Catalog # MBS2533107
Unit / Price
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Typical Testing Data/Standard Curve (for reference only)
Product Name

VWFCP/ADAMTS13 (Von Willebrand Factor Cleaving Protease), CLIA Kit

Popular Item
Also Known As

Human VWFCP/ADAMTS13 (Von Willebrand Factor Cleaving Protease) CLIA Kit

Product Synonym Names
TTP; vWF-CP; C9orf8; ADAM metallopeptidase with thrombospondin type 1 motif, 13
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Sequence Length
1427
OMIM
274150
Species Reactivity
Specificity
This kit recognizes natural and recombinant VWFCP/ADAMTS13. No significant cross-reactivity or interference between VWFCP/ADAMTS13 and analogues was observed.
Assay Type
Sandwich
Detection Range
62.5-4000pg/mL
Sensitivity
Min: 37.5pg/mL; Max: 4000pg/mL
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Product Note
Our CLIA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of VWFCP/ADAMTS13 clia kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
VWFCP/ADAMTS13 clia kit
Intended Uses: This CLIA kit applies to the in vitro quantitative determination of VWFCP/ADAMTS13 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to VWFCP/ADAMTS13. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for VWFCP/ADAMTS13 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain VWFCP/ADAMTS13, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of VWFCP/ADAMTS13. You can calculate the concentration of VWFCP/ADAMTS13 in the samples by comparing the RLU value of the samples to the standard curve.

Typical Testing Data/Standard Curve (for reference only) of VWFCP/ADAMTS13 clia kit
VWFCP/ADAMTS13 clia kit Typical Testing Data/Standard Curve (for reference only) image
Sample Manual Insert of MBS2533107. Click to request current manual
NCBI/Uniprot data below describe general gene information for VWFCP/ADAMTS13. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,864 Da
NCBI Official Full Name
von Willebrand factor-cleaving protease
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 13
NCBI Official Symbol
ADAMTS13  [Similar Products]
NCBI Official Synonym Symbols
VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13
  [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 13
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 13
UniProt Synonym Protein Names
von Willebrand factor-cleaving protease; vWF-CP; vWF-cleaving protease
UniProt Gene Name
ADAMTS13  [Similar Products]
UniProt Synonym Gene Names
C9orf8; ADAM-TS 13; ADAM-TS13; ADAMTS-13; vWF-CP; vWF-cleaving protease  [Similar Products]
UniProt Entry Name
ATS13_HUMAN
NCBI Summary for VWFCP/ADAMTS13
This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for VWFCP/ADAMTS13
ADAMTS13: Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding; Protease; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted; Extracellular matrix; EC 3.4.24.87

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; endoplasmic reticulum lumen

Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; calcium ion binding

Biological Process: integrin-mediated signaling pathway; platelet activation; protein amino acid O-linked glycosylation; cellular protein metabolic process; glycoprotein metabolic process; cell-matrix adhesion; response to toxin; peptide catabolic process; protein processing; post-translational protein modification; proteolysis

Disease: Thrombotic Thrombocytopenic Purpura, Congenital
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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