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WARS recombinant protein

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Catalog # MBS8250023
Unit / Price
  0.01 mg  /  $200 +1 FREE 8GB USB
  0.05 mg  /  $435 +1 FREE 8GB USB
  0.5 mg  /  $2,670 +3 FREE 8GB USB
WARS recombinant protein
Product Name

WARS, Recombinant Protein

Popular Item
Also Known As

Recombinant Human WARS Protein

Product Synonym Names
IFI53; WRS; Tryptophan--tRNA ligase cytoplasmic; Interferon-induced protein 53; IFP53; Tryptophanyl-tRNA synthetase; TrpRS; hWRS
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
471
Sequence
MGSSHHHHHH SSGLVPRGSH MPNSEPASLL ELFNSIATQG ELVRSLKAGN ASKDEIDSAV KMLVSLKMSY KAAAGEDYKA DCPPGNPAPT SNHGPDATEA EEDFVDPWTV QTSSAKGIDY DKLIVRFGSS KIDKELINRI ERATGQRPHH FLRRGIFFSH RDMNQVLDAY ENKKPFYLYT GRGPSSEAMH VGHLIPFIFT KWLQDVFNVP LVIQMTDDEK YLWKDLTLDQ AYSYAVENAK DIIACGFDIN KTFIFSDLDY MGMSSGFYKN VVKIQKHVTF NQVKGIFGFT DSDCIGKISF PAIQAAPSFS NSFPQIFRDR TDIQCLIPCA IDQDPYFRMT RDVAPRIGYP KPALLHSTFF PALQGAQTKM SASDPNSSIF LTDTAKQIKT KVNKHAFSGG RDTIEEHRQF GGNCDVDVSF MYLTFFLEDD DKLEQIRKDY TSGAMLTGEL KKALIEVLQP LIAEHQARRK EVTDEIVKEF MTPRKLSFDF Q
OMIM
M77804 mRNA
3D Structure
ModBase 3D Structure for P23381
Host
E Coli
Species Reactivity
Human
Purity/Purification
Greater than 95% as determined by reducing SDS-PAGE.
Form/Format
Lyophilized from a 0.2 muM filtered solution of 20mM Tris, 150mM NaCl, pH 8.0.
Endotoxin
Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
Directions for Use
Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Preparation and Storage
Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.
Other Notes
Small volumes of WARS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
WARS recombinant protein
Recombinant Human WARS Protein is produced by our E Coli expression system and the target gene encoding Met1-Gln471 is expressed with a 6His tag at the N-terminus.
Applications Tested/Suitable for WARS recombinant protein
ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
NCBI/Uniprot data below describe general gene information for WARS. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,852 Da
NCBI Official Full Name
tryptophan--tRNA ligase, cytoplasmic isoform a
NCBI Official Synonym Full Names
tryptophanyl-tRNA synthetase
NCBI Official Symbol
NCBI Official Synonym Symbols
IFI53; IFP53; GAMMA-2
  [Similar Products]
NCBI Protein Information
tryptophan--tRNA ligase, cytoplasmic
UniProt Protein Name
Tryptophan--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Interferon-induced protein 53; IFP53
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
IFI53; WRS; IFP53; TrpRS; hWRS  [Similar Products]
UniProt Entry Name
SYWC_HUMAN
NCBI Summary for WARS
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for WARS
WARS: Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression. Belongs to the class-I aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - tryptophan; EC 6.1.1.2; Ligase; Translation

Chromosomal Location of Human Ortholog: 14q32.31

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; tryptophan-tRNA ligase activity

Biological Process: negative regulation of cell proliferation; regulation of angiogenesis; translation; tRNA aminoacylation for protein translation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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