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WHSC1 peptide :: WHSC1 / MMSET Peptide

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Catalog # MBS425083
Unit / Price
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  0.1 mg  /  $190 +1 FREE 8GB USB
WHSC1 peptide
Product Name

WHSC1 / MMSET, Peptide

Full Product Name

WHSC1 / MMSET Immunizing Peptide

Product Synonym Names
WHSC1 antibody; Wolf-Hirschhorn syndrome candidate 1 antibody; NSD2 antibody; TRX5 antibody; MMSET antibody; REIIBP antibody; KIAA1090 antibody; trithorax/ash1-related protein 5 antibody; multiple myeloma SET domain protein antibody; IL-5 promoter REII-region-binding protein antibody; FLJ23286 antibody; MGC176638 antibody; OTTHUMP00000196943 antibody; Wolf-Hirschhorn syndrome candidate 1 protein antibody; multiple myeloma SET domain containing protein type III antibody
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 4; NC_000004.11 (1873123..1983934). Location: 4p16.3
3D Structure
ModBase 3D Structure for O96028
Species Reactivity
100ug of dried peptide
Corresponding Antibody
The peptide was used in the production of MBS421196 - Goat Anti-WHSC1 / MMSET Antibody.
It is currently untested in blocking applications.
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of WHSC1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for WHSC1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_579877.1; NP_579878.1; NP_579890.1; NP_579889.1; NP_015627.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
152,258 Da
NCBI Official Full Name
histone-lysine N-methyltransferase NSD2 isoform 1
NCBI Official Synonym Full Names
Wolf-Hirschhorn syndrome candidate 1
NCBI Official Symbol
WHSC1  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
histone-lysine N-methyltransferase NSD2; trithorax/ash1-related protein 5; nuclear SET domain-containing protein 2; IL5 promoter REII region-binding protein; probable histone-lysine N-methyltransferase NSD2; multiple myeloma SET domain containing protein type III
UniProt Protein Name
Histone-lysine N-methyltransferase NSD2
UniProt Synonym Protein Names
Multiple myeloma SET domain-containing protein; MMSET; Nuclear SET domain-containing protein 2; NSD2; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 protein
UniProt Gene Name
WHSC1  [Similar Products]
UniProt Synonym Gene Names
KIAA1090; MMSET; NSD2; TRX5; MMSET; NSD2; WHSC1  [Similar Products]
UniProt Entry Name
NCBI Summary for WHSC1
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq, Jul 2008]
UniProt Comments for WHSC1
Function: Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. Ref.4 Ref.16 Ref.20

Catalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. Ref.20

Subcellular location: Nucleus. Chromosome

Potential Ref.5 Ref.17. Isoform 4: Cytoplasm Ref.5 Ref.17.

Tissue specificity: Widely expressed. Ref.2

Involvement in disease: A chromosomal aberration involving WHSC1 is a cause of multiple myeloma tumors. Translocation t(4;14)(p16.3;q32.3) with IgH.WHSC1 is located in the Wolf-Hirschhorn syndrome (WHS) critical region. WHS results from by sub-telomeric deletions in the short arm of chromosome 4. WHSC1 is deleted in every case, however deletion of linked genes contributes to both the severity of the core characteristics and the presence of the additional syndromic problems. Ref.18

Sequence similarities: Belongs to the histone-lysine methyltransferase family. SET2 subfamily.Contains 1 AWS domain.Contains 1 HMG box DNA-binding domain.Contains 4 PHD-type zinc fingers.Contains 1 post-SET domain.Contains 2 PWWP domains.Contains 1 SET domain.

Sequence caution: The sequence BAA83042.2 differs from that shown. Reason: Erroneous initiation.
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