NP_003871.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,402 Da
NCBI Official Full Name
WNT1-inducible-signaling pathway protein 3 isoform 1
NCBI Official Synonym Full Names
WNT1 inducible signaling pathway protein 3
NCBI Protein Information
WNT1-inducible-signaling pathway protein 3
UniProt Protein Name
WNT1-inducible-signaling pathway protein 3
UniProt Synonym Protein Names
CCN family member 6
UniProt Synonym Gene Names
UniProt Entry Name
WISP3_HUMAN
NCBI Summary for WISP3
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for WISP3
WISP3: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis. Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood (PPAC). PPAC is an autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Cell cycle regulation; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: extracellular space; proteinaceous extracellular matrix
Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding; growth factor activity
Biological Process: cell-cell signaling; regulation of cell growth; cell adhesion; signal transduction
Disease: Arthropathy, Progressive Pseudorheumatoid, Of Childhood
Research Articles on WISP3
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Products associated with WISP3 sirna
Diseases associated with WISP3 sirna
Organs/Tissues associated with WISP3 sirna
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