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WNK1 blocking peptide :: p65 Blocking Peptide

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Catalog # MBS8221722
Unit / Price
  1 mg  /  $195 +1 FREE 8GB USB
  5 mg  /  $435 +1 FREE 8GB USB
WNK1 blocking peptide
Product Name

p65 (WNK1), Blocking Peptide

Also Known As

p65 (pT60) Blocking Peptide

Product Synonym Names
HSN2; KDP; KIAA0344; PRKWNK1; Serine/threonine-protein kinase WNK1; Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1
Antibody/Peptide Pairs
p65 peptide (MBS8221722) is used for blocking the activity of p65 antibody (MBS8224397)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
2642
OMIM
201300
3D Structure
ModBase 3D Structure for Q9H4A3
Host
Synthetic
Species Reactivity
Human, Mouse, Rat, Porcine
Purity/Purification
>85%
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of WNK1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
WNK1 blocking peptide
The peptide is used to block Anti-p65 (pT60) Antibody reactivity.
Applications Tested/Suitable for WNK1 blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for WNK1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
299,725 Da
NCBI Official Full Name
serine/threonine-protein kinase WNK1 isoform 4
NCBI Official Synonym Full Names
WNK lysine deficient protein kinase 1
NCBI Official Symbol
NCBI Official Synonym Symbols
KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167
  [Similar Products]
NCBI Protein Information
serine/threonine-protein kinase WNK1
UniProt Protein Name
Serine/threonine-protein kinase WNK1
UniProt Synonym Protein Names
Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1
UniProt Gene Name
UniProt Synonym Gene Names
HSN2; KDP; KIAA0344; PRKWNK1; p65; hWNK1  [Similar Products]
UniProt Entry Name
WNK1_HUMAN
NCBI Summary for WNK1
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
UniProt Comments for WNK1
WNK1: a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization.

Protein type: Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; Wnk family

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; protein binding; chloride channel inhibitor activity; protein kinase inhibitor activity; ATP binding; phosphatase binding

Biological Process: regulation of cellular process; peptidyl-threonine phosphorylation; negative regulation of protein kinase activity; neuron development; ion transport; protein amino acid phosphorylation

Disease: Pseudohypoaldosteronism, Type Iic; Neuropathy, Hereditary Sensory And Autonomic, Type Iia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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