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Wrn recombinant protein :: Werner syndrome ATP-dependent helicase homolog (Wrn) Recombinant Protein

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Catalog # MBS1066596
Unit / Price
  0.5 mg (E-Coli)  /  $930 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $930 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,155 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,155 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,330 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,330 +1 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,790 +2 FREE 8GB USB
  1 mg (Yeast)  /  $1,790 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,285 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,620 +3 FREE 8GB USB
Wrn recombinant protein
Product Name

Werner syndrome ATP-dependent helicase homolog (Wrn), Recombinant Protein

Full Product Name

Recombinant Mouse Werner syndrome ATP-dependent helicase homolog (Wrn) , partial

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
713-866; Helicase C-terminal domain
Sequence
DLKPFLVRKA SSAWEFEGPT IIYCPSRKMT EQVTAELGKL NLACRTYHAG MKISERKDVH HRFLRDEIQC VVATVAFGMG INKADIRKVI HYGAPKEMES YYQEIGRAGR DGLQSSCHLL WAPADFNTSR NLLIEIHDEK FRLYKLKMMV KMEK
3D Structure
ModBase 3D Structure for O09053
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Wrn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Wrn recombinant protein
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3 to 5 DNA helicase activity, and is also a 3 to 5 exonuclease. Based on interactions between this protein and Ku70
80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
NCBI/Uniprot data below describe general gene information for Wrn. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
157,204 Da
NCBI Official Full Name
Werner syndrome ATP-dependent helicase homolog
NCBI Official Synonym Full Names
Werner syndrome RecQ like helicase
NCBI Official Symbol
NCBI Official Synonym Symbols
AI846146
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NCBI Protein Information
Werner syndrome ATP-dependent helicase homolog
UniProt Protein Name
Werner syndrome ATP-dependent helicase homolog
UniProt Synonym Protein Names
Exonuclease WRN (EC:3.1.-.-)
UniProt Gene Name
UniProt Comments for Wrn
Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (). Plays a role in double-strand break repair after gamma-irradiation ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withWrn recombinant protein
 Reference Product  PubMed Publications
 Wrnip1 recombinant protein  >9 publications with Wrn and Wrnip1
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