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Wt1 recombinant protein :: Wilms tumor protein homolog (Wt1) Recombinant Protein

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Catalog # MBS957212
Unit / Price
  0.05 mg (E-Coli)  /  $865 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $940 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,160 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,170 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,270 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,280 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,410 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,440 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,690 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $1,940 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,195 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,285 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,290 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,390 +4 FREE 8GB USB
SDS-PAGE
Product Name

Wilms tumor protein homolog (Wt1), Recombinant Protein

Popular Item
Full Product Name

Recombinant Mouse Wilms tumor protein homolog (Wt1)

Product Gene Name

Wt1 recombinant protein

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sequence Positions
1-449aa, Full length protein
Sequence
MGSDVRDLNA LLPAVSSLGG GGGGCGLPVS GARQWAPVLD FAPPGASAYG SLGGPAPPPA PPPPPPPPHS FIKQEPSWGG AEPHEEQCLS AFTLHFSGQF TGTAGACRYG PFGPPPPSQA SSGQARMFPN APYLPSCLES QPTIRNQGYS TVTFDGAPSY GHTPSHHAAQ FPNHSFKHED PMGQQGSLGE QQYSVPPPVY GCHTPTDSCT GSQALLLRTP YSSDNLYQMT SQLECMTWNQ MNLGATLKGM AAGSSSSVKW TEGQSNHGIG YESENHTAPI LCGAQYRIHT HGVFRGIQDV RRVSGVAPTL VRSASETSEK RPFMCAYPGC NKRYFKLSHL QMHSRKHTGE KPYQCDFKDC ERRFSRSDQL KRHQRRHTGV KPFQCKTCQR KFSRSDHLKT HTRTHTGKTS EKPFSCRWHS CQKKFARSDE LVRHHNMHQR NMTKLHVAL
3D Structure
ModBase 3D Structure for P22561
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mouse
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Wt1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
Wt1 recombinant protein
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline
glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm s tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
SDS-PAGE of Wt1 recombinant protein
Wt1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Wt1. It may not necessarily be applicable to this product.
NCBI GI #
139779
NCBI GeneID
22431
NCBI Accession #
P22561.1 [Other Products]
UniProt Primary Accession #
P22561 [Other Products]
UniProt Secondary Accession #
A2A402[Other Products]
UniProt Related Accession #
P22561[Other Products]
Molecular Weight
54,943 Da
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NCBI Official Full Name
Wilms tumor protein homolog
NCBI Official Synonym Full Names
Wilms tumor 1 homolog
NCBI Official Symbol
Wt1  [Similar Products]
NCBI Official Synonym Symbols
Wt-1; D630046I19Rik
  [Similar Products]
NCBI Protein Information
Wilms tumor protein homolog
UniProt Protein Name
Wilms tumor protein homolog
Protein Family
Wilms tumor protein
UniProt Gene Name
Wt1  [Similar Products]
UniProt Synonym Gene Names
Wt-1  [Similar Products]
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NCBI Summary for Wt1
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. [provided by RefSeq, Apr 2013]
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UniProt Comments for Wt1
Transcription factor that plays an important role in cellular development and cell survival (PubMed:16467207, PubMed:16920711, PubMed:17537799). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (). Regulates the expression of numerous target genes, including EPO (PubMed:16467207). Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:17167543). Isoform 1 has lower affinity for DNA, and can bind RNA.
Research Articles on Wt1
1. both the local oxygen environment and WT1, which enhances KDR expression, contribute to sex-specific Sox9 expression in developing murine gonads
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Wt1 recombinant protein
 Products by Pathway  Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
Diseases associated with Wt1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1641 publications with Wt1 and Neoplasms
 Wilms Tumor Antibodies  >1554 publications with Wt1 and Wilms Tumor
 Kidney Diseases Antibodies  >769 publications with Wt1 and Kidney Diseases
 Leukemia, Myeloid Antibodies  >378 publications with Wt1 and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >315 publications with Wt1 and Leukemia, Myeloid, Acute
 Carcinoma Antibodies  >291 publications with Wt1 and Carcinoma
 Chromosome Aberrations Antibodies  >179 publications with Wt1 and Chromosome Aberrations
 Denys-Drash Syndrome Antibodies  >173 publications with Wt1 and Denys-Drash Syndrome
 Hematologic Diseases Antibodies  >165 publications with Wt1 and Hematologic Diseases
 Adenocarcinoma Antibodies  >156 publications with Wt1 and Adenocarcinoma
Organs/Tissues associated with Wt1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >830 publications with Wt1 and Kidney
 Blood Antibodies  >456 publications with Wt1 and Blood
 Testis Antibodies  >135 publications with Wt1 and Testis
 Embryonic Tissue Antibodies  >123 publications with Wt1 and Embryonic Tissue
 Lung Antibodies  >118 publications with Wt1 and Lung
 Ovary Antibodies  >112 publications with Wt1 and Ovary
 Heart Antibodies  >77 publications with Wt1 and Heart
 Brain Antibodies  >76 publications with Wt1 and Brain
 Uterus Antibodies  >42 publications with Wt1 and Uterus
 Pancreas Antibodies  >11 publications with Wt1 and Pancreas
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