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WWP1 cdna clone

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Catalog # MBS1267912
Unit / Price
  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
WWP1 cdna clone
Product Name

WWP1, cDNA Clone

Popular Item
Full Product Name

WWP1 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggccactg cttcaccaag gtctgatact agtaataacc acagtggaag gttgcagtta caggtaactg tttctagtgc caaacttaaa agaaaaaaga actggttcgg aacagcaata tatacagaag tagttgtaga tggagaaatt acgaaaacag caaaatccag tagttcttct aatccaaaat gggatgaaca gctaactgta aatgttacgc cacagactac attggaattt caagtttgga gccatcgcac tttaaaagca gatgctttat taggaaaagc aacgatagat ttgaaacaag ctctgttgat acacaataga aaattggaaa gagtgaaaga acaattaaaa ctttccttgg aaaacaagaa tggcatagca caaactggtg aattgacagt tgtgcttgat ggattggtga ttgagcaaga aaatataaca aactgcagct catctccaac catagaaata caggaaaatg gtgatgcctt acatgaaaat ggagagcctt cagcaaggac aactgccagg ttggctgttg aaggcacgaa tggaatagat aatcatgtac ctacaagcac tctagtccaa aactcatgct gctcgtatgt agttaatgga gacaacacac cttcatctcc gtctcaggtt gctgccagac ccaaaaatac accagctcca aaaccactcg catctgagcc tgccgatgac actgttaatg gagaatcatc ctcatttgca ccaactgata atgcgtctgt cacgggtact ccagtagtgt ctgaagaaaa tgccttgtct ccaaattgca ctagtactac tgttgaagat cctccagttc aagaaatact gacttcctca gaaaacaatg aatgtattcc ttctaccagt gcagaattgg aatctgaagc tagaagtata ttagagcctg acacctctaa ttctagaagt agttctgctt ttgaagcagc caaatcaaga cagccagatg ggtgtatgga tcctgtacgg cagcagtctg ggaatgccaa cacagaaacc ttgccatcag ggtgggaaca aagaaaagat cctcatggta gaacctatta tgtggatcat aatactcgaa ctaccacatg ggagagacca caacctttac ctccaggttg ggaaagaaga gttgatgatc gtagaagagt ttattatgtg gatcataaca ccagaacaac aacgtggcag cggcctacca tggaatctgt ccgaaatttt gaacagtggc aatctcagcg gaaccaattg cagggagcta tgcaacagtt taaccaacga tacctctatt cggcttcaat gttagctgca gaaaatgacc cttatggacc tttgccacca ggctgggaaa aaagagtgga ttcaacagac agggtttact ttgtgaatca taacacaaaa acaacccagt gggaagatcc aagaactcaa ggcttacaga atgaagaacc cctgccagaa ggctgggaaa ttagatatac tcgtgaaggt gtaaggtact ttgttgatca taacacaaga acaacaacat tcaaagatcc tcgcaatggg aagtcatctg taactaaagg tggtccacaa attgcttatg aacgcggctt taggtggaag cttgctcact tccgttattt gtgccagtct aatgcactac ctagtcatgt aaagatcaat gtgtcccggc agacattgtt tgaagattcc ttccaacaga ttatggcatt aaaaccctat gacttgagga ggcgcttata tgtaatattt agaggagaag aaggacttga ttatggtggc ctagcgagag aatggttttt cttgctttca catgaagttt tgaacccaat gtattgctta tttgagtatg cgggcaagaa caactattgt ctgcagataa atccagcatc aaccattaat ccagaccatc tttcatactt ctgtttcatt ggtcgtttta ttgccatggc actatttcat ggaaagttta tcgatactgg tttctcttta ccattctaca agcgtatgtt aagtaaaaaa cttactatta aggatttgga atctattgat actgaatttt ataactccct tatctggata agagataaca acattgaaga atgtggctta gaaatgtact tttctgttga catggagatt ttgggaaaag ttacttcaca tgacctgaag ttgggaggtt ccaatattct ggtgactgag gagaacaaag atgaatatat tggtttaatg acagaatggc gtttttctcg aggagtacaa gaacagacca aagctttcct tgatggtttt aatgaagttg ttcctcttca gtggctacag tacttcgatg aaaaagaatt agaggttatg ttgtgtggca tgcaggaggt tgacttggca gattggcaga gaaatactgt ttatcgacat tatacaagaa acagcaagca aatcatttgg ttttggcagt ttgtgaaaga gacagacaat gaagtaagaa tgcgactatt gcagttcgtc actggaacct gccgtttacc tctaggagga tttgctgagc tcatgggaag taatgggcct caaaagtttt gcattgaaaa agttggcaaa gacacttggt taccaagaag ccatacatgt tttaatcgct tggatctacc accatataag agttatgaac aactaaagga aaaacttctt tttgcaatag aagagacaga gggatttgga caagaatga
OMIM
602307
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of WWP1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for WWP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
– Da
NCBI Official Full Name
Homo sapiens WW domain containing E3 ubiquitin protein ligase 1, mRNA
NCBI Official Synonym Full Names
WW domain containing E3 ubiquitin protein ligase 1
NCBI Official Symbol
NCBI Official Synonym Symbols
AIP5; Tiul1; hSDRP1
  [Similar Products]
NCBI Protein Information
NEDD4-like E3 ubiquitin-protein ligase WWP1
UniProt Protein Name
NEDD4-like E3 ubiquitin-protein ligase WWP1
UniProt Synonym Protein Names
Atrophin-1-interacting protein 5; AIP5; TGIF-interacting ubiquitin ligase 1; Tiul1; WW domain-containing protein 1
UniProt Gene Name
UniProt Synonym Gene Names
AIP5; Tiul1  [Similar Products]
UniProt Entry Name
WWP1_HUMAN
NCBI Summary for WWP1
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
UniProt Comments for WWP1
WWP1: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; Ligase

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: entry of virus into host cell; negative regulation of transcription, DNA-dependent; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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