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XDH recombinant protein :: Xanthine dehydrogenase/oxidase (XDH), partial Recombinant Protein

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Catalog # MBS958091
Unit / Price
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  0.05 mg (E-Coli)  /  $495 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $655 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $665 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $725 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $820 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $895 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,005 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,015 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,030 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,055 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,500 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,530 +1 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,615 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,010 +2 FREE 8GB USB
Testing Data
Product Name

Xanthine dehydrogenase/oxidase (XDH), partial, Recombinant Protein

Popular Item
Full Product Name

Recombinant Human Xanthine dehydrogenase/oxidase (XDH), partial

Product Synonym Names
Xanthine dehydrogenase/oxidase; Including the following 2 domains:; Xanthine dehydrogenase; XD; EC=1.17.1.4; Xanthine oxidase; XO; EC=1.17.3.2; Xanthine oxidoreductase
Product Synonym Gene Name
XDH; XDHA[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS958091 COA
Sequence Positions
1234-1333. Partial.
Sequence
GSIPIEFRVS LLRDCPNKKA IYASKAVGEP PLFLAASIFF AIKDAIRAAR AQHTGNNVKE LFRLDSPATP EKIRNACVDK FTTLCVTGVP ENCKPWSVRV
OMIM
607633
3D Structure
ModBase 3D Structure for P47989
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of XDH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
XDH recombinant protein
XDH; XDHA

Testing Data of XDH recombinant protein
XDH recombinant protein Testing Data image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for XDH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
146,424 Da
NCBI Official Full Name
xanthine dehydrogenase/oxidase
NCBI Official Synonym Full Names
xanthine dehydrogenase
NCBI Official Symbol
NCBI Official Synonym Symbols
XO; XOR
  [Similar Products]
NCBI Protein Information
xanthine dehydrogenase/oxidase; xanthine oxidoreductase
UniProt Protein Name
Xanthine dehydrogenase/oxidase
UniProt Synonym Protein Names
Xanthine oxidoreductase; XOR
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
XDHA; XD; XO; XOR  [Similar Products]
UniProt Entry Name
XDH_HUMAN
NCBI Summary for XDH
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
UniProt Comments for XDH
XDH: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). Defects in XDH are the cause of xanthinuria type 1 (XU1). Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol. Belongs to the xanthine dehydrogenase family.

Protein type: Oxidoreductase; EC 1.17.1.4; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 1.17.3.2; Secondary Metabolites Metabolism - caffeine; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 2p23.1

Cellular Component: extracellular space; peroxisome; cytosol

Molecular Function: molybdopterin cofactor binding; 2 iron, 2 sulfur cluster binding; UDP-N-acetylmuramate dehydrogenase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors; protein homodimerization activity; electron carrier activity; FAD binding; iron ion binding; xanthine dehydrogenase activity; xanthine oxidase activity

Biological Process: lactation; caspase activation; xanthine catabolic process; negative regulation of protein kinase B signaling cascade; negative regulation of protein amino acid phosphorylation; negative regulation of endothelial cell differentiation; nucleobase, nucleoside and nucleotide metabolic process; negative regulation of endothelial cell proliferation; purine nucleotide catabolic process; purine base metabolic process

Disease: Xanthinuria, Type I
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with XDH recombinant protein
 Reference Product  PubMed Publications
 BTN1A1 recombinant protein  >1 publications with XDH and BTN1A1
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