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XPO5 blocking peptide

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Catalog # MBS9221393
Unit / Price
  0.1 mg  /  $155 +1 FREE 8GB USB
XPO5 blocking peptide
Product Name

XPO5, Blocking Peptide

Full Product Name

XPO5 Antibody (C-term) Blocking Peptide

Product Synonym Names
Exportin-5; Exp5; Ran-binding protein 21; XPO5; KIAA1291; RANBP21
Product Synonym Gene Name
KIAA1291; RANBP21[Similar Products]
Antibody/Peptide Pairs
XPO5 peptide (MBS9221393) is used for blocking the activity of XPO5 antibody (MBS9213268)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
607845
3D Structure
ModBase 3D Structure for Q9HAV4
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Nucleus. Cytoplasm. Note: Shuttles between the nucleus and the cytoplasm
Tissue Location
Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and pancreas
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of XPO5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
XPO5 blocking peptide
Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.
NCBI/Uniprot data below describe general gene information for XPO5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
136,311 Da
NCBI Official Full Name
Exportin-5
NCBI Official Synonym Full Names
exportin 5
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
exportin-5
UniProt Protein Name
Exportin-5
UniProt Synonym Protein Names
Ran-binding protein 21
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
KIAA1291; RANBP21; Exp5  [Similar Products]
UniProt Entry Name
XPO5_HUMAN
NCBI Summary for XPO5
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
UniProt Comments for XPO5
Exportin-5: mediates the nuclear export of proteins bearing double-stranded RNA binding domains and double-stranded RNA. Overexpression enhances RNA interference mediated by shRNAs and miRNAs. In the nucleus it binds cooperatively to its cargo and to Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. Exp5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear export; Karyopherin; Nuclear import; RNA-binding

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: mRNA binding; protein binding; Ran GTPase binding; RNA binding

Biological Process: pre-microRNA export from nucleus; protein export from nucleus; RNA-mediated gene silencing
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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