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anti-XRCC4 antibody :: anti-Human XRCC4 Antibody

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Catalog # MBS851102
Unit / Price
  0.1 mg  /  $215 +1 FREE 8GB USB
Western Blot (WB)
Product Name

XRCC4, Antibody

Also Known As

XRCC4 Antibody

Product Synonym Names
DNA-repair protein XRCC4; X-ray repair cross-complementing protein 4
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
336
OMIM
194363
3D Structure
ModBase 3D Structure for Q13426
Species Reactivity
Human
Specificity
XRCC4 antibody detects endogenous levels of total XRCC4 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from Internal of human XRCC4.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-XRCC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-XRCC4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-XRCC4 antibody
WB: 1:500~1:1000
ELISA: 1:20000

Western Blot (WB) of anti-XRCC4 antibody
Western blot analysis of extracts from COLO205 cells, using XRCC4 antibody.
anti-XRCC4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for XRCC4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,372 Da
NCBI Official Full Name
DNA repair protein XRCC4 isoform 2
NCBI Official Synonym Full Names
X-ray repair cross complementing 4
NCBI Official Symbol
XRCC4  [Similar Products]
NCBI Official Synonym Symbols
SSMED
  [Similar Products]
NCBI Protein Information
DNA repair protein XRCC4
UniProt Protein Name
DNA repair protein XRCC4
UniProt Synonym Protein Names
X-ray repair cross-complementing protein 4
Protein Family
UniProt Gene Name
XRCC4  [Similar Products]
NCBI Summary for XRCC4
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternative splicing generates several transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for XRCC4
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Product References and Citations for anti-XRCC4 antibody
Ling Chen, J. Biol. Chem., Aug 2000; 275: 26196. Jérôme Drouet, J. Biol. Chem., Feb 2005; 280: 7060-7069. Ulf Grawunder, J. Biol. Chem., Sep 1998; 273: 24708. Ray Leber, J. Biol. Chem., Jan 1998; 273: 1794.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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