NP_001158263.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32,842 Da
NCBI Official Full Name
mitogen-activated protein kinase kinase kinase MLT isoform 3
NCBI Official Synonym Full Names
sterile alpha motif and leucine zipper containing kinase AZK
NCBI Official Synonym Symbols
MLTK; AV006891; MLTKbeta; MLTKalpha; B230120H23Rik [Similar Products]
NCBI Protein Information
mitogen-activated protein kinase kinase kinase MLT
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase MLT
UniProt Synonym Protein Names
Leucine zipper- and sterile alpha motif kinase ZAK; MLK-like mitogen-activated protein triple kinase; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK
UniProt Synonym Gene Names
UniProt Entry Name
MLTK_MOUSE
UniProt Comments for ZAK
ZAK: a mixed-lineage kinase containing a leucine-zipper (LZ) and a sterile-alpha motif (SAM). It is reported to activate the JNK/SAPK and NF-kappaB pathways.
Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily
Cellular Component: cytoplasm; nucleus
Molecular Function: transferase activity; protein serine/threonine kinase activity; MAP kinase kinase kinase activity; metal ion binding; transferase activity, transferring phosphorus-containing groups; magnesium ion binding; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: response to radiation; activation of MAPKK activity; positive regulation of apoptosis; DNA damage checkpoint; MAPKKK cascade; cytoskeleton organization and biogenesis; cell cycle arrest; cell cycle; phosphorylation; cell cycle checkpoint; protein amino acid phosphorylation; activation of JNK activity
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Pathways associated with ZAK sirna
Diseases associated with ZAK sirna
Organs/Tissues associated with ZAK sirna
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