Dentin Sialo (DSP) ELISA Kit for Human

Name: Human DSP ELISA Kit; Dentin Sialo; MyBioSource
Brand: MyBioSource
SKU: MBS008159
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS008159

Background: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used to determine the level of DSP (hereafter termed "analyte") in undiluted original… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Dentin Sialo Protein (DSP), ELISA Kit

Full Product Name

Human Dentin Sialo Protein ELISA Kit

Product Gene Name

DSP elisa kit

Species Reactivity

Human

Assay Type

Quantitative Sandwich

Detection Range

0.625ng/ml-20ng/ml

Sensitivity

0.1ng/ml

Preparation and Storage

Store all reagents at 2-8 degree C

Inter-assay Precision

Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Intra-assay Precision

Intra-assay CV (%) is less than 15%.

Molecular Weight

331,774 Da

OMIM

125647

3D Structure

ModBase 3D Structure for P15924

Other Notes

Small volumes of DSP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DSP purchase

MBS008159 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Dentin Sialo Protein (DSP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DSP. The ELISA analytical biochemical technique of the MBS008159 kit is based on DSP antibody-DSP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DSP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DSP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for DSP. It may not necessarily be applicable to this product.

NCBI GI #

58530842

NCBI GeneID

1832

NCBI Accession #

NP_001008844.1

UniProt Primary Accession #

P15924

UniProt Secondary Accession #

O75993; Q14189; Q9UHN4; B2RTT2; D7RX09

UniProt Related Accession #

P15924

GenBank Nucleotide #

NM_001008844.1

NCBI Official Full Name

desmoplakin isoform II

NCBI Official Synonym Full Names

desmoplakin

NCBI Official Symbol

DSP

NCBI Official Synonym Symbols

DP; DPI; DPII

UniProt Protein Name

Desmoplakin

UniProt Synonym Protein Names

250/210 kDa paraneoplastic pemphigus antigen

Protein Family

Desmoplakin

UniProt Gene Name

DSP

UniProt Synonym Gene Names

UniProt Entry Name

DESP_HUMAN

NCBI Protein Information

desmoplakin; desmoplakin I; desmoplakin II; 250/210 kDa paraneoplastic pemphigus antigen

NCBI Summary for DSP

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]

UniProt Comments for DSP

Desmoplakin: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. Belongs to the plakin or cytolinker family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 6p24

Cellular Component: desmosome; mitochondrion; basolateral plasma membrane; plasma membrane; cornified envelope; intermediate filament; fascia adherens; nucleus

Molecular Function: protein binding, bridging; protein binding; protein kinase C binding; structural constituent of cytoskeleton; cell adhesion molecule binding; structural molecule activity

Biological Process: keratinocyte differentiation; epidermis development; cell-cell adhesion; wound healing; apoptosis; intermediate filament organization; peptide cross-linking; cell structure disassembly during apoptosis

Disease: Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma; Arrhythmogenic Right Ventricular Dysplasia, Familial, 8; Keratosis Palmoplantaris Striata Ii; Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis; Skin Fragility-woolly Hair Syndrome; Epidermolysis Bullosa, Lethal Acantholytic

Research Articles on DSP

1. Arrhythmogenic right ventricular cardiomyopathy patients of a three-generation Spanish family with a novel nonsense genetic variation in the DSP gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DSP elisa kit

Reference Product	PubMed Publications
PKP2 elisa kit	>38 publications with DSP and PKP2
JUP elisa kit	>38 publications with DSP and JUP
DSC1 elisa kit	>8 publications with DSP and DSC1
PKP1 elisa kit	>7 publications with DSP and PKP1
PKP4 elisa kit	>5 publications with DSP and PKP4
CDH5 elisa kit	>1 publications with DSP and CDH5
PKP3 elisa kit	>1 publications with DSP and PKP3

Pathways associated with DSP elisa kit

Products by Pathway	Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies	Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
Apoptotic Cleavage Of Cellular Proteins Pathway antibodies	Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
Apoptotic Execution Phase Pathway antibodies	Apoptotic Execution Phase Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram

Diseases associated with DSP elisa kit

Disease Name	Pubmed Publications
Poisoning Antibodies	>235 publications with DSP and Poisoning
Neoplasms Antibodies	>113 publications with DSP and Neoplasms
Heart Diseases Antibodies	>106 publications with DSP and Heart Diseases
Brain Diseases Antibodies	>88 publications with DSP and Brain Diseases
Disease Models, Animal Antibodies	>60 publications with DSP and Disease Models, Animal
Heart Defects, Congenital Antibodies	>46 publications with DSP and Heart Defects, Congenital
Nerve Degeneration Antibodies	>32 publications with DSP and Nerve Degeneration
Necrosis Antibodies	>29 publications with DSP and Necrosis
Inflammation Antibodies	>26 publications with DSP and Inflammation
Liver Diseases Antibodies	>24 publications with DSP and Liver Diseases

Organs/Tissues associated with DSP elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>581 publications with DSP and Brain
Mouth Antibodies	>189 publications with DSP and Mouth
Heart Antibodies	>188 publications with DSP and Heart
Skin Antibodies	>141 publications with DSP and Skin
Muscle Antibodies	>134 publications with DSP and Muscle
Bone Antibodies	>122 publications with DSP and Bone
Testis Antibodies	>98 publications with DSP and Testis
Liver Antibodies	>72 publications with DSP and Liver
Lung Antibodies	>69 publications with DSP and Lung
Kidney Antibodies	>53 publications with DSP and Kidney