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(Rhesus Macaque) Galactocerebrosidase (GALC) Macaca Mulatta Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1001491

MBS1001491 is a recombinant protein targeting GALC. Also known as Recombinant Macaca mulatta (Rhesus macaque) Galactocerebrosidase (GALC). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$3180 / 1 mg (E-Coli) +3 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
(Rhesus macaque) Galactocerebrosidase (GALC), Recombinant Protein
Full Product Name
Recombinant Macaca mulatta (Rhesus macaque) Galactocerebrosidase (GALC)
Product Gene Name
GALC recombinant protein
Product Synonym Gene Name
GALC
Product Synonym Names
Recombinant (Rhesus macaque) Galactocerebrosidase (GALC); Galactocerebrosidase; GALCERase EC= 3.2.1.46; Galactocerebroside beta-galactosidase Galactosylceramidase Galactosylceramide beta-galactosidase
Sequence
YVLDDSDGLG REFDGIGAVS GGGATSRLLV NYPEPYRSQI LDYLFKPNFG ASLHILKVEI GGDGQTTDGT EPSHMHYALD ENYFRGYEWW LMKEAKKRNP NITLIGLPWS FPGWLGKGFD WPYVNLQLTA YYVVTWIVGA KRYHDLDIDY IGIWNERSYN ANYIKILRKM LNSQGLQRVK IIASDNLWES ISAAMLLDAE LFKVVDVIGA HYPGTHSVKD ARLTGKKLWS SEDFSTLNSD TGAGCWGRIL NQNYVNGYMT STIAWNLVAS YYEQLPYGRC GLMTAQEPWS GHYVVESPVW VSAHTTQFTQ PGWYYLKTVG HLEKGGSYVA LTDGLGNLTI IIETMSHKHS KCIRPFLPYF NVSQQFATFV LKGSFSEIPE LQVWYTKLGK TSERFLFKQL DSLWLLDSNG SFTLKLQEDE LFTLTTLTTG RKGSYLPPPK SQRFPSTYKD DFNVDYPFFS EAPNFADQTG VFEYFTNMED PGEHHFTLRQ VLNQRPITWA ADASNTISII GDYNWTNLTI KCDVYIETPD TGGVFIAGRV NKGGILIRSA RGIFFWIFAN GSYRVTGDLA GWIIYALGHV EVTAKTWYTL TLTIKGRFAS GMLNDKSLWT DIPVNFPKNG WAAIGTHSFE FAQFDNFHVE ATR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
77,090 Da
Sequence Positions
43-685
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 7; NC_007864.1 (151114169..151171568, complement). Location: chromosome: 7
3D Structure
ModBase 3D Structure for O02791
Species
Macaca mulatta (Rhesus macaque)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GALC recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GALC. It may not necessarily be applicable to this product.

NCBI GI #
112982788
NCBI GeneID
693322
NCBI Accession #
NP_001037727.1
UniProt Primary Accession #
O02791
UniProt Related Accession #
O02791
GenBank Nucleotide #
NM_001044262.2
NCBI Official Full Name
galactocerebrosidase
NCBI Official Symbol
GALC
UniProt Protein Name
Galactocerebrosidase
UniProt Synonym Protein Names
Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta-galactosidase
Protein Family
4-carboxy-4-hydroxy-2-oxoadipic acid aldolase
UniProt Gene Name
GALC
UniProt Synonym Gene Names
GALCERase
UniProt Entry Name
GALC_MACMU
NCBI Protein Information
galactocerebrosidase; GALCERase; galactocerebroside beta-galactosidase; galactosylceramide beta-galactosidase

UniProt Comments for GALC

Function: Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon

By similarity.

Catalytic activity: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.

Subcellular location: Lysosome

By similarity.

Involvement in disease: Note=Defects in GALC are the cause of globoid cell leukodystrophy (GLD); also known as Krabbe disease. This deficiency results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin.

Sequence similarities: Belongs to the glycosyl hydrolase 59 family.

Caution: It is uncertain whether Met-1 or Met-17 is the initiator.

Sequence caution: The sequence AAB58575.1 differs from that shown. Reason: Erroneous initiation.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GALC recombinant protein

 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram

Diseases associated with GALC recombinant protein

 Disease Name  Pubmed Publications
 Leukodystrophy, Globoid Cell Antibodies  >85 publications with GALC and Leukodystrophy, Globoid Cell
 Immune System Diseases Antibodies  >23 publications with GALC and Immune System Diseases
 Autoimmune Diseases Antibodies  >20 publications with GALC and Autoimmune Diseases
 Neoplasms Antibodies  >13 publications with GALC and Neoplasms
 Inflammation Antibodies  >11 publications with GALC and Inflammation
 Drug Toxicity Antibodies  >9 publications with GALC and Drug Toxicity
 Glioma Antibodies  >8 publications with GALC and Glioma
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >6 publications with GALC and Encephalomyelitis, Autoimmune, Experimental
 Cardiovascular Diseases Antibodies  >5 publications with GALC and Cardiovascular Diseases
 Cerebral Infarction Antibodies  >5 publications with GALC and Cerebral Infarction
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