Human TLL1 Recombinant Protein – Cat# MBS1005757

Tolloid-Like Protein 1 (TLL1) Human Recombinant Protein

Name: TLL1 Recombinant Protein; Tolloid-Like Protein 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1005757
Price: 855 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1005757

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar… More details

$855 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tolloid-like protein 1 (TLL1), Recombinant Protein

Full Product Name

Recombinant Human Tolloid-like protein 1 (TLL1) , partial

Product Gene Name

TLL1 recombinant protein

Sequence

AATSRTERIW PGGVIPYVIG GNFTGSQRAM FKQAMRHWEK HTCVTFIERS DEESYIVFTY RPCGCCSYVG RRGNGPQAIS IGKNCDKFGI VVHELGHVIG FWHEHTRPDR DNHVTIIREN IQPGQEYNFL KMEPGEVNSL GERYDFDSIM HYARNTFSRG MFLDTILPSR DDNGIRPAIG QRTRLSKGDI AQARKLYRCP ACG

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

44,186 Da

Sequence Positions

148-350aa; Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

606742

3D Structure

ModBase 3D Structure for O43897

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TLL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLL1 purchase

MBS1005757 is a recombinant protein targeting TLL1. Also known as Recombinant Human Tolloid-like protein 1 (TLL1) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TLL1. It may not necessarily be applicable to this product.

NCBI GI #

325652110

NCBI GeneID

7092

NCBI Accession #

NP_001191689.1

UniProt Primary Accession #

O43897

UniProt Secondary Accession #

Q96AN3; Q9NQS4; B2RMU2

UniProt Related Accession #

O43897

GenBank Nucleotide #

NM_001204760.1

NCBI Official Full Name

tolloid-like protein 1 isoform 2

NCBI Official Synonym Full Names

tolloid like 1

NCBI Official Symbol

TLL1

NCBI Official Synonym Symbols

TLL; ASD6

UniProt Protein Name

Tolloid-like protein 1

Protein Family

Dorsal-ventral patterning tolloid-like protein

UniProt Gene Name

TLL1

UniProt Synonym Gene Names

TLL

NCBI Protein Information

tolloid-like protein 1

NCBI Summary for TLL1

This gene encodes an astacin-like, zinc-dependent, metalloprotease that belongs to the peptidase M12A family. This protease processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Studies in mice suggest that this gene plays multiple roles in the development of mammalian heart, and is essential for the formation of the interventricular septum. Allelic variants of this gene are associated with atrial septal defect type 6. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

UniProt Comments for TLL1

Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.

Research Articles on TLL1

1. Multivariate analysis showed rs17047200 AT/TT to be an independent risk factor for HCC (hazard ratio, 1.78; P = .008).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TLL1 recombinant protein

Reference Product	PubMed Publications
BMP1 recombinant protein	>20 publications with TLL1 and BMP1
BMP4 recombinant protein	>1 publications with TLL1 and BMP4
COL7A1 recombinant protein	>1 publications with TLL1 and COL7A1

Pathways associated with TLL1 recombinant protein

Products by Pathway	Pathway Diagram
Anchoring Fibril Formation Pathway antibodies	Anchoring Fibril Formation Pathway Diagram
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies	Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
Collagen Biosynthesis And Modifying Enzymes Pathway antibodies	Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Crosslinking Of Collagen Fibrils Pathway antibodies	Crosslinking Of Collagen Fibrils Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Diseases associated with TLL1 recombinant protein

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>7 publications with TLL1 and Congenital Abnormalities
Disease Models, Animal Antibodies	>3 publications with TLL1 and Disease Models, Animal
Fetal Death Antibodies	>2 publications with TLL1 and Fetal Death
Fibrosis Antibodies	>2 publications with TLL1 and Fibrosis
Inflammation Antibodies	>2 publications with TLL1 and Inflammation
Atrial Septal Defect 6 Antibodies	>2 publications with TLL1 and Atrial Septal Defect 6
Neoplasm Metastasis Antibodies	>1 publications with TLL1 and Neoplasm Metastasis
Abnormalities, Multiple Antibodies	>1 publications with TLL1 and Abnormalities, Multiple
Learning Disorders Antibodies	>1 publications with TLL1 and Learning Disorders

Organs/Tissues associated with TLL1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>31 publications with TLL1 and Bone
Embryonic Tissue Antibodies	>6 publications with TLL1 and Embryonic Tissue
Skin Antibodies	>4 publications with TLL1 and Skin
Brain Antibodies	>4 publications with TLL1 and Brain
Liver Antibodies	>2 publications with TLL1 and Liver
Amniotic Fluid Antibodies	>2 publications with TLL1 and Amniotic Fluid
Kidney Antibodies	>1 publications with TLL1 and Kidney
Ovary Antibodies	>1 publications with TLL1 and Ovary