Rabies Virus RABVgp4 Recombinant Protein – Cat# MBS1005806

Glycoprotein G (G) (RABVgp4) Rabies Virus Recombinant Protein

Name: RABVgp4 Recombinant Protein; Glycoprotein G (G); Rabies Virus; MyBioSource
Brand: MyBioSource
SKU: MBS1005806
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1005806

Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro… More details

$1025 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glycoprotein G (G) (RABVgp4), Recombinant Protein

Full Product Name

Recombinant Rabies virus Glycoprotein G (G)

Product Gene Name

RABVgp4 recombinant protein

Product Synonym Names

Recombinant Glycoprotein G (G); Glycoprotein G

Sequence

KFPIYTIPDK LGPWSPIDIH HLSCPNNLVV EDEGCTNLSG FSYMELKVGY ISAIKMNGFT CTGVVTEAET YTNFVGYVTT TFKRKHFRPT PDACRAAYNW KMAGDPRYEE SLHNPYPDYH WLRTVKTTKE SLVIISPSVA DLDPYDRSLH SRVFPGGNCS GVAVSSTYCS TNHDYTIWMP ENPRLGMSCD IFTNSRGKRA SKGSETCGFV DERGLYKSLK GACKLKLCGV LGLRLMDGTW VAMQTSNETK WCPPGQLVNL HDFRSDEIEH LVVEELVKKR EECLDALESI MTTKSVSFRR LSHLRKLVPG FGKAYTIFNK TLMEADAHYK SVRTWNEIIP SKGCLRVGGR CHPHVNGVFF NGIILGPDGN VLIPEMQSSL LQQHMELLVS SVIPLMHPLA DPSTVFKNGD EAEDFVEVHL PDVHERISGV DLGLPNWGKY

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Molecular Weight

64kD

Sequence Positions

20-459aa, Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

NC_001542.1 (3291..4964)

3D Structure

ModBase 3D Structure for P08667

Species

Rabies virus (strain Pasteur vaccins / PV) (RABV)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RABVgp4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RABVgp4 purchase

MBS1005806 is a recombinant protein targeting RABVgp4. Also known as Recombinant Rabies virus Glycoprotein G (G). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for RABVgp4. It may not necessarily be applicable to this product.

NCBI GI #

9627201

NCBI GeneID

1489856

NCBI Accession #

NP_056796.1

UniProt Primary Accession #

P08667

UniProt Related Accession #

1206374A

GenBank Nucleotide #

NC_001542.1

NCBI Official Full Name

transmembrane glycoprotein G

NCBI Official Symbol

RABVgp4

UniProt Protein Name

Glycoprotein G

UniProt Gene Name

UniProt Entry Name

VGLG_RABVP

NCBI Protein Information

transmembrane glycoprotein G

UniProt Comments for RABVgp4

Function: Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein G and thereby facilitate rabies virus entry into cells

By similarity.

Subunit structure: Homotrimer. Interacts with matrix protein

By similarity.

Subcellular location: Virion membrane; Single-pass type I membrane protein

Potential.

Post-translational modification: Glycosylated and palmitoylated by host. Glycosylation is crucial for glycoprotein export at the cell surface

By similarity.

Biotechnological use: Primary surface antigen capable of inducing and reacting with virus-neutralizing antibodies. Almost all human and veterinary vaccines are based on the functional aspects of the G protein.

Miscellaneous: Arg-352 is highly involved in rabies virus pathogenicity. Its mutation dramatically attenuates the virus

By similarity.

Sequence similarities: Belongs to the lyssavirus glycoprotein family.

Research Articles on RABVgp4

1. human PCBP2 specifically and selectively interacts with rabies virus glycoprotein mRNA and this interaction may contribute to the post-transcriptional regulation of glycoprotein expression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.