Mouse PTGIS Recombinant Protein – Cat# MBS1009693

Prostacyclin Synthase (PTGIS) Mouse Recombinant Protein

Name: PTGIS Recombinant Protein; Prostacyclin Synthase; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1009693
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1009693

MBS1009693 is a recombinant protein targeting Ptgis. Also known as Recombinant Mouse Prostacyclin synthase (Ptgis). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Prostacyclin synthase (Ptgis), Recombinant Protein

Full Product Name

Recombinant Mouse Prostacyclin synthase (Ptgis)

Product Gene Name

Ptgis recombinant protein

Product Synonym Gene Name

Ptgis; Cyp8

Product Synonym Names

Prostacyclin synthase; EC=5.3.99.4; Prostaglandin I2 synthase

Sequence

MSWAALLGLL AVLLLLLLLL SRRRARRPGE PPLDLGSIPW LGHALEFGRD AASFLTRMKE KHGDIFTVLV GGRYVTVLLD PHSYDTVVWE LRTRLDFHPY AIFLMERIFD LQLPNFNPSE EKARMKPTLM HRDLQALTEA MYTNLRTVLL GDSTEAGSGW QETGLLEFSY NALLSAGYLT LYGVEASPRT HESQAQDRVH SADVFHTFRQ LDLLLPKLAR GSLSAGDKDH ACSVKNRLWK LLSPARLASR ADRSSWLESY LRHLEEMGVS EEMQARALVL QLWATQGNMG PTAFWLLLFL LKNPEALAAV RAELKHTVWQ AEQPVSQMTT LPQKILDSMP VLDSVLNETL RLTAAPFITR EVMADLALPM ADGREFSLRR GDRLLLFPFL SPQKDPEIYT EPEVFKYNRF LNPDGSEKKD FYKDGKRLKN YNMPWGAGHN QCLGKSYAIN SIKQFVVLLL THFDLELGSE DTEVPEFDLS RYGFGLMQPE EDVPIRYRAR L

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

57,047 Da

Sequence Positions

1-501

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for O35074

Species

Mus musculus (Mouse)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Ptgis recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Ptgis. It may not necessarily be applicable to this product.

NCBI GI #

6679535

NCBI GeneID

19223

NCBI Accession #

NP_032994.1

UniProt Primary Accession #

O35074

UniProt Related Accession #

O35074

GenBank Nucleotide #

NM_008968.3

NCBI Official Full Name

prostacyclin synthase

NCBI Official Synonym Full Names

prostaglandin I2 (prostacyclin) synthase

NCBI Official Symbol

Ptgis

NCBI Official Synonym Symbols

Cyp8; Pgis; Cyp8a1

UniProt Protein Name

Prostacyclin synthase

UniProt Synonym Protein Names

Prostaglandin I2 synthase

Protein Family

Prostacyclin synthase

UniProt Gene Name

Ptgis

UniProt Synonym Gene Names

Cyp8

UniProt Entry Name

PTGIS_MOUSE

NCBI Protein Information

prostacyclin synthase

UniProt Comments for Ptgis

PTGIS: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2). Belongs to the cytochrome P450 family.

Protein type: Endoplasmic reticulum; Isomerase; Membrane protein, integral; Lipid Metabolism - arachidonic acid; EC 5.3.99.4

Cellular Component: extracellular space; membrane; endoplasmic reticulum; cytoplasm; integral to membrane; caveola; nucleus

Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; metal ion binding; prostaglandin-I synthase activity; heme binding; isomerase activity; monooxygenase activity

Biological Process: regulation of apoptosis; positive regulation of angiogenesis; inhibition of NF-kappaB transcription factor; negative regulation of nitric oxide biosynthetic process; negative regulation of inflammatory response; response to hypoxia; decidualization; lipid metabolic process; prostaglandin biosynthetic process; fatty acid metabolic process; embryo implantation; fatty acid biosynthetic process; prostaglandin metabolic process

Research Articles on Ptgis

1. Taken together, our in vitro and in vivo findings show that prostacyclin is secreted from neovessels formed as a result of CNS inflammation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Ptgis recombinant protein

Reference Product	PubMed Publications
Ptgs2 recombinant protein	>11 publications with Ptgis and Ptgs2
Ptgs1 recombinant protein	>8 publications with Ptgis and Ptgs1
Ptges recombinant protein	>7 publications with Ptgis and Ptges
Ptgir recombinant protein	>5 publications with Ptgis and Ptgir
Nos3 recombinant protein	>3 publications with Ptgis and Nos3
Tbxas1 recombinant protein	>3 publications with Ptgis and Tbxas1
Ptgds recombinant protein	>3 publications with Ptgis and Ptgds
Ptges2 recombinant protein	>2 publications with Ptgis and Ptges2
Tbxa2r recombinant protein	>1 publications with Ptgis and Tbxa2r
Hpgds recombinant protein	>1 publications with Ptgis and Hpgds

Diseases associated with Ptgis recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>13 publications with Ptgis and Cardiovascular Diseases
Hypertension Antibodies	>8 publications with Ptgis and Hypertension
Heart Diseases Antibodies	>6 publications with Ptgis and Heart Diseases
Brain Diseases Antibodies	>5 publications with Ptgis and Brain Diseases
Myocardial Infarction Antibodies	>5 publications with Ptgis and Myocardial Infarction
Inflammation Antibodies	>3 publications with Ptgis and Inflammation
Atherosclerosis Antibodies	>2 publications with Ptgis and Atherosclerosis
Liver Neoplasms Antibodies	>2 publications with Ptgis and Liver Neoplasms
Liver Diseases Antibodies	>2 publications with Ptgis and Liver Diseases
Hemorrhage Antibodies	>2 publications with Ptgis and Hemorrhage

Organs/Tissues associated with Ptgis recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>7 publications with Ptgis and Muscle
Heart Antibodies	>6 publications with Ptgis and Heart
Liver Antibodies	>2 publications with Ptgis and Liver
Intestine Antibodies	>2 publications with Ptgis and Intestine
Brain Antibodies	>2 publications with Ptgis and Brain
Lung Antibodies	>2 publications with Ptgis and Lung
Mammary Gland Antibodies	>1 publications with Ptgis and Mammary Gland
Joint Antibodies	>1 publications with Ptgis and Joint
Embryonic Tissue Antibodies	>1 publications with Ptgis and Embryonic Tissue